Most patients with insults to the spinal cord or central nervous system suffer from
excruciating, unrelenting, chronic pain that is largely resistant to treatment. This condition …

Pathological pain, consisting of tissue injury-induced inflammatory and nerve injury-induced
neuropathic pain, is an expression of neuronal plasticity. One component of this is that the …

Pain inhibition has been the focus in research concerning endogenous mechanisms of pain
modulation. However, recent electrophysiological, anatomical, and neurochemical studies …

Recent advances in pain research illustrate the analytical power of modern neurosciences
in a field previously accessible only to methods of systems biology. Novel molecular and …

LTP is often studied as a model of synaptic plasticity. Plasticity in pain control systems may
involve mechanisms similar to those involved in learning. We recently reported LTP of both …

Much research has been undertaken in the field of pain in an attempt to find an effective
treatment. Insights into the underlying mechanisms of pain have been gained from studies …

Nociceptors and neurons in the central nervous system (CNS) that receive nociceptive input
show remarkable plasticity in response to injury. This plasticity is thought to underlie the …

Pain is an extremely complex process that involves the interaction of an array of
neurotransmitters and neuromodulators at all levels of the neuraxis. Identification of the …

Background: Disinhibition of neurons in the superficial spinal dorsal horn, via microglia–
neuron signaling leading to disruption of chloride homeostasis, is a potential cellular …

Neuropathic pain develops from a lesion or disease affecting the somatosensory system.
Translational investigations of neuropathic pain by using different animal models reveal that …