The objective of the present study was to determine the ability of 17β-estradiol (E2) and
conjugated forms of E2 (E2 conjugated to BSA [E2-BSA] and a novel conjugate, E2 …

The objective of the present study was to determine how rapidly estradiol (E2) was able to
suppress the secretion of LH in ovariectomized (OVX) ewes and to evaluate the ability of …

We studied the effects of 17β-estradiol (E2) on luteinizing hormone (LH) and follicle-
stimulating hormone (FSH) release induced by drugs that activate different intracellular …

The in vivo suppression of LH by 17β-estradiol (E2) has been documented frequently.
However, the demonstration of a direct inhibitory action of E2, in contrast to a stimulatory …

Background We demonstrated that E2 conjugated to BSA (E2BSA) induces a rapid
membrane-initiated inhibition of LH secretion followed hours later by a slight increase in LH …

Acute intravenous administration of the phytoestrogen genistein (G) blocks the gonadotropin-
releasing hormone-(GnRH)-induced rise of luteinizing hormone (LH) in ovariectomized rats …

Dispersed pituitary cells from adult female rats were preincubated for different time periods
(0–12 h) in the absence or presence of 10− 9 moestradiol (E2) or 4-hydroxyoestradiol (4 …

There is evidence that GnRH and its binding sites are expressed in numerous extrapituitary
tissues, including the primate ovary. However, the factors that regulate ovarian GnRH and its …

In the absence of estrogen (E), the selective E receptor modulator tamoxifen (TX) has two
agonist effects in the rat pituitary: induction of progesterone receptor (PR)-dependent GnRH …

The specific role of each oestrogen receptor (ER) isoform (α and β) and site (nucleus and
plasma membrane) in LH release was determined in ovariectomized (OVX) rats injected …