OBJECTIVE—Adenoviral delivery of hepatocyte growth factor (HGF) to rodent islets
improves islet graft survival and function, markedly reducing the number of islets required to …

Hepatocyte growth factor (HGF) increases beta cell proliferation and function in rat insulin
promoter (RIP)-targeted transgenic mice. RIP-HGF mouse islets also function superiorly to …

Recent advances in human islet transplantation have highlighted the need for expanding
the pool of β-cells available for transplantation. We have developed three transgenic models …

Hepatocyte growth factor (HGF) is produced in pancreatic mesenchyme-derived cells and in
islet cells. In vitro, HGF increases the insulin content and proliferation of islets. To study the …

Recent clinical studies have documented that human islet transplantation has the potential
to replace pancreatic endocrine function in patients with type 1 diabetes. These studies have …

Background. It is crucial for clinical islet transplantation to find a procedure to improve the
success rate of insulin independence after islet transplantation. In the present study, we …

Purpose Ex vivo gene therapy can improve the outcome of islet transplantation for treating
type I diabetes. Hepatocyte growth factor (HGF) increases β-cell proliferation and promotes …

Type I diabetes is an autoimmune disease that results in destructive depletion of the insulin-
producing beta cells in the islets of Langerhans in pancreas. With the knowledge that …

Clinical studies have demonstrated that islet transplantation may be a useful procedure to
replace beta cell function in patients with Type 1 diabetes. Islet transplantation faces many …

Islet transplantation for diabetes is limited by the availability of human islet donors.
Hepatocyte growth factor (HGF) is a potent β-cell mitogen and survival factor and improves …