Abstract Alzheimer's disease (AD), which is characterized by extracellular accumulation of
amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most …

Depression, anxiety, and dementia are spectra of the most common symptoms experienced
by patients with a wide range of diseases. The symptoms often concur and frequently wax …

The locus coeruleus is the main noradrenergic nucleus of the brain and is often affected in
neurodegenerative diseases. Recently, magnetic resonance imaging with specific T1 …

Early cognitive deficits in Alzheimer's disease (AD) seem to be correlated to dysregulation of
glutamate receptors evoked by amyloid-beta (Aβ) peptide. Aβ interference with the activity of …

Objective: Cognitive impairments are common in Parkinson's disease (PD) and can even
occur in the early stages. The default mode network (DMN) is highly relevant for cognitive …

Abstract Objective People with Parkinson disease (PD) frequently develop dementia, which
is associated with neocortical deposition of alpha‐synuclein (α‐syn) in Lewy bodies and …

Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related
neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by dopamine depletion in the striatum. One consistent pathophysiological hallmark of PD is …

Neuroimaging advances over the past several decades have provided increased
understanding of the structural and functional brain changes that occur with Parkinson's …

Apathy, depression, and anxiety are among the most important non-motor signs of
Parkinson's disease (PD). This may be encountered at early stages of illness and represent …