The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …

The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …

Advances in neuroscience have resulted in the development of new diagnostic and
therapeutic agents for potential use in the central nervous system (CNS). However, the …

Medical treatment options for central nervous system (CNS) diseases are limited due to the
inability of most therapeutic agents to penetrate the blood–brain barrier (BBB). Although a …

Ultrasound-mediated blood–brain barrier (BBB) disruption has garnered focus as a method
of delivering normally impenetrable drugs into the brain. Numerous studies have …

Brain drug delivery is a major challenge for therapy of central nervous system (CNS)
diseases. Biochemical modifications of drugs or drug nanocarriers, methods of local …

Despite recent advances in blood–brain barrier (BBB) research, it remains a significant
hurdle for the pharmaceutical treatment of brain diseases. Focused ultrasound (FUS) is one …

The range of therapeutic treatment options for central nervous system (CNS) diseases is
greatly limited by the blood-brain barrier (BBB). While a variety of strategies to circumvent …

The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …

The blood–brain barrier (BBB) is a protective element of the neurovascular unit (NVU)
surrounded by astrocytes, pericytes, extracellular matrix, and the tight junctional complex …