The blood-brain barrier: Physiology and strategies for drug delivery
The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …
reflecting the unique requirements of the brain. In this review, following a brief historical …
Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system
M Aryal, CD Arvanitis, PM Alexander… - Advanced drug delivery …, 2014 - Elsevier
The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
Progress and problems in the application of focused ultrasound for blood–brain barrier disruption
N Vykhodtseva, N McDannold, K Hynynen - Ultrasonics, 2008 - Elsevier
Advances in neuroscience have resulted in the development of new diagnostic and
therapeutic agents for potential use in the central nervous system (CNS). However, the …
therapeutic agents for potential use in the central nervous system (CNS). However, the …
Facilitation of drug transport across the blood–brain barrier with ultrasound and microbubbles
S Meairs - Pharmaceutics, 2015 - mdpi.com
Medical treatment options for central nervous system (CNS) diseases are limited due to the
inability of most therapeutic agents to penetrate the blood–brain barrier (BBB). Although a …
inability of most therapeutic agents to penetrate the blood–brain barrier (BBB). Although a …
Ultrasound-mediated blood–brain barrier disruption for drug delivery: a systematic review of protocols, efficacy, and safety outcomes from preclinical and clinical …
Ultrasound-mediated blood–brain barrier (BBB) disruption has garnered focus as a method
of delivering normally impenetrable drugs into the brain. Numerous studies have …
of delivering normally impenetrable drugs into the brain. Numerous studies have …
Promising approaches to circumvent the blood–brain barrier: progress, pitfalls and clinical prospects in brain cancer
IT Papademetriou, T Porter - Therapeutic delivery, 2015 - Taylor & Francis
Brain drug delivery is a major challenge for therapy of central nervous system (CNS)
diseases. Biochemical modifications of drugs or drug nanocarriers, methods of local …
diseases. Biochemical modifications of drugs or drug nanocarriers, methods of local …
Focused ultrasound-mediated drug delivery through the blood–brain barrier
A Burgess, K Shah, O Hough… - Expert review of …, 2015 - Taylor & Francis
Despite recent advances in blood–brain barrier (BBB) research, it remains a significant
hurdle for the pharmaceutical treatment of brain diseases. Focused ultrasound (FUS) is one …
hurdle for the pharmaceutical treatment of brain diseases. Focused ultrasound (FUS) is one …
Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound
The range of therapeutic treatment options for central nervous system (CNS) diseases is
greatly limited by the blood-brain barrier (BBB). While a variety of strategies to circumvent …
greatly limited by the blood-brain barrier (BBB). While a variety of strategies to circumvent …
Development of novel therapeutics targeting the blood–brain barrier: from barrier to carrier
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …
Recent advances towards overcoming the blood–brain barrier
The blood–brain barrier (BBB) is a protective element of the neurovascular unit (NVU)
surrounded by astrocytes, pericytes, extracellular matrix, and the tight junctional complex …
surrounded by astrocytes, pericytes, extracellular matrix, and the tight junctional complex …