Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes
P Lu, R Hontecillas, CW Philipson… - Current drug …, 2014 - ingentaconnect.com
Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of the LANCL
protein family, which is broadly expressed throughout the body. LANCL2 is the molecular …
protein family, which is broadly expressed throughout the body. LANCL2 is the molecular …
Lanthionine synthetase C-like 2-based therapeutics
J Bassaganya-Riera, AC Barrios, R Gandour… - US Patent …, 2017 - Google Patents
Established LANCL2 agonists such as abscisic acid (ABA) and NSC61610 exert anti-
inflammatory activity in a broad range of diseases models ranging from IBD to dia betes and …
inflammatory activity in a broad range of diseases models ranging from IBD to dia betes and …
Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2
P Lu, R Hontecillas, WT Horne, A Carbo, M Viladomiu… - PLoS …, 2012 - journals.plos.org
Background Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of
the eukaryotic lanthionine synthetase component C-Like protein family involved in signal …
the eukaryotic lanthionine synthetase component C-Like protein family involved in signal …
An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease
A Carbo, RD Gandour, R Hontecillas… - Journal of medicinal …, 2016 - ACS Publications
Lanthionine synthetase C-like 2 (LANCL2), a novel therapeutic target for inflammatory and
autoimmune diseases and diabetes, exerts anti-inflammatory and insulin-sensitizing effects …
autoimmune diseases and diabetes, exerts anti-inflammatory and insulin-sensitizing effects …
Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics
The rates of type 2 diabetes (T2D) are rising to epidemic proportions in the US and
worldwide. While current T2D medications are efficacious, significant side effects have …
worldwide. While current T2D medications are efficacious, significant side effects have …
Identification of a high affinity binding site for abscisic acid on human lanthionine synthetase component C-like protein 2
E Cichero, C Fresia, L Guida, V Booz, E Millo… - The international journal …, 2018 - Elsevier
Lanthionine synthetase component C-like protein 2 (LANCL2) has been identified as the
mammalian receptor mediating the functional effects of the universal stress hormone …
mammalian receptor mediating the functional effects of the universal stress hormone …
Treating Autoimmune Diseases With LANCL2 Therapeutics: A Novel Immunoregulatory Mechanism for Patients With Ulcerative Colitis and Crohn's Disease
N Tubau-Juni, R Hontecillas, AJ Leber… - Inflammatory Bowel …, 2024 - academic.oup.com
Lanthionine synthetase C-like 2 (LANCL2) therapeutics have gained increasing recognition
as a novel treatment modality for a wide range of autoimmune diseases. Genetic ablation of …
as a novel treatment modality for a wide range of autoimmune diseases. Genetic ablation of …
New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists
N Scarano, F Di Palma, N Origlia, F Musumeci… - Pharmaceutics, 2023 - mdpi.com
The lanthionine synthetase C-like (LANCL) proteins include LANCL2, which is expressed in
the central nervous system (CNS) and in peripheral tissues. LANCL2 exhibits …
the central nervous system (CNS) and in peripheral tissues. LANCL2 exhibits …
LanCL1 protects prostate cancer cells from oxidative stress via suppression of JNK pathway
Prostate cancer (PCa) is the most commonly diagnosed malignancy in male. Numerous
studies have focused on the molecular mechanisms of carcinogenesis and progression …
studies have focused on the molecular mechanisms of carcinogenesis and progression …
[PDF][PDF] Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis
JE Nielsen, MA Hansen, M JÃ - European Journal of Histochemistry, 2003 - ejh.it
Abstract LANCL1 (LanC-like protein 1) is related to the bacterial LanC (lanthionine
synthetase C) family, which is involved in the biosynthesis of antimicrobial peptides. Highest …
synthetase C) family, which is involved in the biosynthesis of antimicrobial peptides. Highest …