Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes

P Lu, R Hontecillas, CW Philipson… - Current drug …, 2014 - ingentaconnect.com
Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of the LANCL
protein family, which is broadly expressed throughout the body. LANCL2 is the molecular …

Lanthionine synthetase C-like 2-based therapeutics

J Bassaganya-Riera, AC Barrios, R Gandour… - US Patent …, 2017 - Google Patents
Established LANCL2 agonists such as abscisic acid (ABA) and NSC61610 exert anti-
inflammatory activity in a broad range of diseases models ranging from IBD to dia betes and …

Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2

P Lu, R Hontecillas, WT Horne, A Carbo, M Viladomiu… - PLoS …, 2012 - journals.plos.org
Background Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of
the eukaryotic lanthionine synthetase component C-Like protein family involved in signal …

An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease

A Carbo, RD Gandour, R Hontecillas… - Journal of medicinal …, 2016 - ACS Publications
Lanthionine synthetase C-like 2 (LANCL2), a novel therapeutic target for inflammatory and
autoimmune diseases and diabetes, exerts anti-inflammatory and insulin-sensitizing effects …

Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics

P Lu, DR Bevan, SN Lewis, R Hontecillas… - Journal of molecular …, 2011 - Springer
The rates of type 2 diabetes (T2D) are rising to epidemic proportions in the US and
worldwide. While current T2D medications are efficacious, significant side effects have …

Identification of a high affinity binding site for abscisic acid on human lanthionine synthetase component C-like protein 2

E Cichero, C Fresia, L Guida, V Booz, E Millo… - The international journal …, 2018 - Elsevier
Lanthionine synthetase component C-like protein 2 (LANCL2) has been identified as the
mammalian receptor mediating the functional effects of the universal stress hormone …

Treating Autoimmune Diseases With LANCL2 Therapeutics: A Novel Immunoregulatory Mechanism for Patients With Ulcerative Colitis and Crohn's Disease

N Tubau-Juni, R Hontecillas, AJ Leber… - Inflammatory Bowel …, 2024 - academic.oup.com
Lanthionine synthetase C-like 2 (LANCL2) therapeutics have gained increasing recognition
as a novel treatment modality for a wide range of autoimmune diseases. Genetic ablation of …

New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists

N Scarano, F Di Palma, N Origlia, F Musumeci… - Pharmaceutics, 2023 - mdpi.com
The lanthionine synthetase C-like (LANCL) proteins include LANCL2, which is expressed in
the central nervous system (CNS) and in peripheral tissues. LANCL2 exhibits …

LanCL1 protects prostate cancer cells from oxidative stress via suppression of JNK pathway

J Wang, Q Xiao, X Chen, S Tong, J Sun, R Lv… - Cell Death & …, 2018 - nature.com
Prostate cancer (PCa) is the most commonly diagnosed malignancy in male. Numerous
studies have focused on the molecular mechanisms of carcinogenesis and progression …

[PDF][PDF] Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis

JE Nielsen, MA Hansen, M Jà- European Journal of Histochemistry, 2003 - ejh.it
Abstract LANCL1 (LanC-like protein 1) is related to the bacterial LanC (lanthionine
synthetase C) family, which is involved in the biosynthesis of antimicrobial peptides. Highest …