The occurrence of malignant neoplasms increases with advancing age. Although aging and
carcinogenesis are basically different processes, they share phenomena such as the …

To determine whether methylation of the hMLH1 promoter is related to increasing age and
gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric …

To clarify the significance of hMLH1 promoter hypermethylation in the development of
medullary-type poorly differentiated colorectal adenocarcinoma, we studied the status of …

DNA methylation of promoter-associated CpG islands may function as an alternate
mechanism of silencing tumor suppressor genes in multiple neoplasias including colorectal …

Introduction Gastric cancer (GC) is one of the leading causes of cancer-related death in Iran.
Genome stability is one of the main genetic issues in cancer biology which is governed via …

Background: Transcriptional silencing of tumour suppressor genes by DNA
hypermethylation plays a crucial role in the progression of gastric cancer. Many genes …

AIM: Hypermethylation of the promoter of the hMLH1 gene, which plays an important role in
mismatch repair during DNA replication, occurs in more than 30% of human gastric cancer …

Hypermethylation of CpG islands in the promoter region is associated with the silencing of a
variety of tumor suppressor genes. DNA repair genes human Mut L homologue 1 (hMLH1) …

Background: Human mutL homolog 1 (hMLH1) is located on chromosome 3q21-23. As a
classic tumor suppressor gene, many researchers have studied the association between …

Silencing of gene expression by aberrant cytosine methylation is a prominent feature of
human tumors, including colorectal cancers. Epigenetic changes of this type play …