Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM

S McGaraughty, KL Chu, RS Bitner… - Journal of …, 2003 - journals.physiology.org
It is well established that the vanilloid receptor, VR1, is an important peripheral mediator of
nociception. VR1 receptors are also located in several brain regions, yet it is uncertain …

Peripheral capsaicin receptors increase in the inflamed rat hindpaw: a possible mechanism for peripheral sensitization

SM Carlton, RE Coggeshall - Neuroscience letters, 2001 - Elsevier
The vanilloid receptor-1 (VR1) is activated by capsaicin, heat and protons and is localized
on primary sensory neurons. The present study investigates whether VR1 increases in the …

Vanilloid receptor VR1-positive afferents are distributed differently at different levels of the rat lumbar spinal cord

SJ Hwang, JG Valtschanoff - Neuroscience letters, 2003 - Elsevier
The vanilloid receptor VR1 renders a group of primary afferents that express it sensitive to
noxious heat and capsaicin, and is thus an important marker for nociceptors. We use double …

The modality‐specific contribution of peptidergic and non‐peptidergic nociceptors is manifest at the level of dorsal horn nociresponsive neurons

J Zhang, DJ Cavanaugh, MI Nemenov… - The Journal of …, 2013 - Wiley Online Library
Key points Ablation of TRPV1+/peptidergic or of MrgprD+/non‐peptidergic nociceptors
produces modality‐specific deficits in the behavioural responses to heat and mechanical …

Vanilloid receptor homologue, VRL1, is expressed by both A-and C-fiber sensory neurons

QP Ma - Neuroreport, 2001 - journals.lww.com
The capsaicin receptor (VR1) homologue, VRL1, is thought to be responsible for
transducing high-threshold heat responses in Aδ-fiber neurons. In the present study, the …

Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates

ER Butelman, TJ Harris, MJ Kreek - Journal of Pharmacology and …, 2004 - ASPET
Capsaicin produces thermal allodynia in animals and humans by acting as an agonist at
vanilloid receptor subtype 1 [VR1; also known as transient receptor potential vanilloid type 1 …

Peripheral and central actions of capsaicin and VR1 receptor

T Sasamura, Y Kuraishi - The Japanese Journal of Pharmacology, 1999 - jstage.jst.go.jp
Vanilloid receptor subtype 1 (VR1), a capsaicin receptor, is expressed in primary sensory
neurons and vagal nerves. Heat and protons as well as capsaicin activate VR1 to induce the …

Immunoreactive TRPV‐2 (VRL‐1), a capsaicin receptor homolog, in the spinal cord of the rat

RD Lewinter, K Skinner, D Julius… - Journal of …, 2004 - Wiley Online Library
The vanilloid receptor‐like 1 protein (VRL‐1, also called TRPV2) is a member of the TRPV
family of proteins and is a homolog of the capsaicin/vanilloid receptor (VR1, or TRPV1) …

TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues

A Baamonde, A Lastra, L Juarez, A Hidalgo… - Brain research …, 2005 - Elsevier
The intraplantar acute administration of 10μg of capsaicin to mice which had received
complete Freund's adjuvant (CFA) 1 week before inhibits the thermal inflammatory …

Spinal administration of capsazepine inhibits noxious evoked responses of dorsal horn neurons in non-inflamed and carrageenan inflamed rats

S Kelly, V Chapman - Brain research, 2002 - Elsevier
Vanilloid VR1 receptors are located in the dorsal horn of the spinal cord. The aim of the
present study was to determine the role of spinal vanilloid receptors (VR1) during …