Serotonin receptor 4 in the hippocampus modulates mood and anxiety
Abstract Serotonin receptor 4 (5-HT4R) plays an important role in regulating mood, anxiety,
and cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like …
and cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like …
Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre-and post-synaptic 5-HT1A receptor expression
PR Albert, F Vahid-Ansari, C Luckhart - Frontiers in behavioral …, 2014 - frontiersin.org
Decreased serotonergic activity has been implicated in anxiety and major depression, and
antidepressants directly or indirectly increase the long-term activity of the serotonin system …
antidepressants directly or indirectly increase the long-term activity of the serotonin system …
Serotonin 5‐HT2C receptors regulate anxiety‐like behavior
LK Heisler, L Zhou, P Bajwa, J Hsu… - Genes, Brain and …, 2007 - Wiley Online Library
Central serotonin (5‐hydroxytryptamine, 5‐HT) systems have been implicated in the
pathophysiology and treatment of anxiety disorders, which are among the world's most …
pathophysiology and treatment of anxiety disorders, which are among the world's most …
The role of the serotonin receptor subtypes 5-HT1A and 5-HT7 and its interaction in emotional learning and memory
O Stiedl, E Pappa, Å Konradsson-Geuken… - Frontiers in …, 2015 - frontiersin.org
Serotonin [5-hydroxytryptamine (5-HT)] is a multifunctional neurotransmitter innervating
cortical and limbic areas involved in cognition and emotional regulation. Dysregulation of …
cortical and limbic areas involved in cognition and emotional regulation. Dysregulation of …
Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity
PR Albert, LM Fiori - Current pharmaceutical design, 2014 - ingentaconnect.com
The etiology of major depression remains unclear, but reduced activity of the serotonin (5-
HT) system remains implicated and treatments that increase 5-HT neurotransmission can …
HT) system remains implicated and treatments that increase 5-HT neurotransmission can …
CREB-mediated synaptogenesis and neurogenesis is crucial for the role of 5-HT1a receptors in modulating anxiety behaviors
J Zhang, CY Cai, HY Wu, LJ Zhu, CX Luo, DY Zhu - Scientific reports, 2016 - nature.com
Abstract Serotonin 1a-receptor (5-HT1aR) has been specifically implicated in the
pathogenesis of anxiety. However, the mechanism underlying the role of 5-HT1aR in anxiety …
pathogenesis of anxiety. However, the mechanism underlying the role of 5-HT1aR in anxiety …
Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function
E Dale, AL Pehrson, T Jeyarajah, Y Li, SC Leiser… - CNS …, 2016 - cambridge.org
The hippocampus plays an important role in emotional and cognitive processing, and both
of these domains are affected in patients with major depressive disorder (MDD). Extensive …
of these domains are affected in patients with major depressive disorder (MDD). Extensive …
Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype
M Angoa-Pérez, MJ Kane, DI Briggs… - ACS chemical …, 2014 - ACS Publications
Reductions in function within the serotonin (5HT) neuronal system have long been proposed
as etiological factors in depression. Selective serotonin reuptake inhibitors (SSRIs) are the …
as etiological factors in depression. Selective serotonin reuptake inhibitors (SSRIs) are the …
The effect of serotonin-targeting antidepressants on neurogenesis and neuronal maturation of the hippocampus mediated via 5-HT1A and 5-HT4 receptors
E Segi-Nishida - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Antidepressant drugs such as selective serotonin reuptake inhibitors (SSRIs) specifically
increase serotonin (5-HT) levels in the synaptic cleft and are widely used to treat mood and …
increase serotonin (5-HT) levels in the synaptic cleft and are widely used to treat mood and …
Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11
TM Eriksson, A Alvarsson, TL Stan, X Zhang… - Molecular …, 2013 - nature.com
Cognitive impairments are common in depression and involve dysfunctional serotonin
neurotransmission. The 5-HT 1B receptor (5-HT 1B R) regulates serotonin transmission, via …
neurotransmission. The 5-HT 1B receptor (5-HT 1B R) regulates serotonin transmission, via …