Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study
Background Plasmodium vivax malaria is characterized by relapses arising from the
hypnozoite stages in the liver. The only currently registered drug for radical treatment to …
hypnozoite stages in the liver. The only currently registered drug for radical treatment to …
CYP2D6 gene resequencing in the Malagasy, a population at the crossroads between Asia and Africa: a pilot study
ER Chan, RK Mehlotra, KA Pirani… - …, 2022 - Taylor & Francis
Background: Plasmodium vivax malaria is endemic in Madagascar, where populations have
genetic inheritance from Southeast Asia and East Africa. Primaquine, a drug of choice for …
genetic inheritance from Southeast Asia and East Africa. Primaquine, a drug of choice for …
CYP2D6 Genetic Variation and Its Implication for Vivax Malaria Treatment in Madagascar
RK Mehlotra, A Gaedigk, RE Howes… - Frontiers in …, 2021 - frontiersin.org
Plasmodium vivax is one of the five human malaria parasite species, which has a wide
geographical distribution and can cause severe disease and fatal outcomes. It has the ability …
geographical distribution and can cause severe disease and fatal outcomes. It has the ability …
Several Plasmodium vivax relapses after correct primaquine treatment in a patient with impaired cytochrome P450 2D6 function
A Martin Ramírez, C Lombardia González… - Malaria Journal, 2020 - Springer
Background Plasmodium vivax malaria is characterized by the presence of dormant liver-
stage parasites, called hypnozoites, which can cause malaria relapses after an initial attack …
stage parasites, called hypnozoites, which can cause malaria relapses after an initial attack …
The association of CYP2D6 gene polymorphisms in the full-length coding region with higher recurrence rate of vivax malaria in Yunnan Province, China
H Huang, Y Dong, Y Xu, Y Deng, C Zhang, S Liu… - Malaria Journal, 2021 - Springer
Background Accumulating evidence suggest that compromised CYP2D6 enzyme activity
caused by gene mutation could contribute to primaquine failure for the radical cure of vivax …
caused by gene mutation could contribute to primaquine failure for the radical cure of vivax …
CYP2D6 activity and the risk of recurrence of Plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study
LW Brasil, F Rodrigues-Soares, AB Santoro… - Malaria journal, 2018 - Springer
Background CYP2D6 pathway mediates the activation of primaquine into active metabolite
(s) in hepatocytes. CYP2D6 is highly polymorphic, encoding CYP2D6 isoforms with normal …
(s) in hepatocytes. CYP2D6 is highly polymorphic, encoding CYP2D6 isoforms with normal …
Association of impaired cytochrome P450 2D6 activity genotype and phenotype with therapeutic efficacy of primaquine treatment for latent Plasmodium vivax malaria
Importance Latent hepaticPlasmodium vivaxhypnozoites provoke repeated clinical attacks
called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity …
called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity …
Association between CYP2D6 phenotype and recurrence of Plasmodium vivax infection in south Korean patients
S Choi, H Choi, SY Park, YG Kwak, JE Song, SY Shin… - Malaria Journal, 2022 - Springer
Background Primaquine is activated by CYP2D6 in the hepatocytes. In Korea, primaquine is
the only hypnozoitocidal agent used for patients with vivax malaria. Thus, patients with poor …
the only hypnozoitocidal agent used for patients with vivax malaria. Thus, patients with poor …
Genetic Variation of G6PD and CYP2D6: Clinical Implications on the Use of Primaquine for Elimination of Plasmodium vivax
AGA Stewart, PA Zimmerman… - Frontiers in …, 2021 - frontiersin.org
Primaquine, an 8-aminoquinoline, is the only medication approved by the World Health
Organization to treat the hypnozoite stage of Plasmodium vivax and P. ovale malaria …
Organization to treat the hypnozoite stage of Plasmodium vivax and P. ovale malaria …
[HTML][HTML] Prevalence of CYP2D6 genotypes and predicted phenotypes in a cohort of Cambodians at high risk for infections with Plasmodium vivax
MD Spring, C Lon, S Sok, D Sea… - The American Journal …, 2020 - ncbi.nlm.nih.gov
Clinical failure of primaquine (PQ) has been demonstrated in people with CYP450 2D6
genetic polymorphisms that result in reduced or no enzyme activity. The distribution of …
genetic polymorphisms that result in reduced or no enzyme activity. The distribution of …