Neurodegenerative diseases encompass a large group of conditions that are clinically and
pathologically diverse yet are linked by a shared pathology of misfolded proteins. The …

Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative
diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional …

Circadian rhythms are physiological and behavioural cycles generated by an endogenous
biological clock, the suprachiasmatic nucleus. The circadian system influences the majority …

The relevance of circadian rhythms and timekeeping for human health has been
increasingly recognized not only by sleep medicine but also by many other medical …

Circadian organization of physiology and behavior is an important biological process that
allows organisms to anticipate and prepare for daily changes and demands. Disruptions in …

Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

Highlights•Neurodegenerative diseases are characterised by disordered sleep/wake
patterns.•Aggregation of soluble proteins is the canonical molecular motif of …

Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in
patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered …

Disturbance of the circadian system, manifested as disrupted daily rhythms of physiologic
parameters such as sleep, activity, and hormone secretion, has long been observed as a …

Circadian rhythm disorders have been classically associated with disorders of abnormal
timing of the sleep–wake cycle, however circadian dysfunction can play a role in a wide …