Vinflunine is a novel bifluorinated vinca alkaloid that appears to differ from other class
members in terms of its tubulin-binding properties and inhibitory effects on microtubule …

Vinflunine (VFL) is a third-generation bifluorinated semi-synthetic vinca alkaloid obtained by
superacidic chemistry from its parent compound, vinorelbine. As with the other vinca …

Vinflunine is a novel third-generation bifluorinated semisynthetic vinca alkaloid that has
been shown to have activity against a variety of solid tumor types including advanced …

Vinflunine is a second-generation Vinca alkaloid distinguished from other related
compounds by differences in tubulin binding affinities and its effects upon microtubule …

Introduction: Vinca alkaloid agents have been widely used in several different types of
malignancies. However, cancer cells, ultimately, develop resistance to these agents …

Vinflunine is a novel microtubule inhibitor of the vinca alkaloid class currently in
development for the treatment of advanced transitional cell carcinoma of the urothelium …

The novel third-generation bifluorinated semisynthetic vinca alkaloid, vinflunine, is a
microtubule inhibitor that shows superior antitumor activity and a favorable safety profile …

Background: Vinflunine is a novel second generation of Vinca alkaloid. The binding of
vinflunine to tubulin and subsequent cellular arrest in mitosis is the core mechanism of this …

15543 Background: Vinflunine (VFL) is a new microtubule inhibitor of the vinca alkaloid
class with clinical activity in TCCU (S. Culine, BJC 2006). This trial was conducted to define …

Objective: To review the pharmacology, pharmacokinetics, in vitro and in vivo efficacy, and
safety profile of vinflunine in the treatment of various solid tumors. Data sources: A literature …