We expressed the cloned μ‐opioid receptor (μR) in high abundance (5.5× 106 sites/cell)
with an amino‐terminal epitope tag (EYMPME) in human embryonic kidney 293 cells. The …

In the present study we examine the role of transmembrane aromatic residues of the δ-
opioid receptor in ligand recognition. Three-dimensional computer modeling of the receptor …

By screening a rat brain cDNA library using a cloned mu opioid receptor cDNA as probe, a
clone was identified that is very similar to both the mu and delta opioid receptor sequences …

Opioids provide excellent pain relief in most patients. Yet the responses of patients to
individual opioids can vary markedly, even among the μ opioids. Understanding this …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

The endogenous opioid system is expressed throughout the brain reinforcement circuitry,
and plays a major role in reward processing, mood control and the development of …