The last two to three years provided several “big steps” regarding our understanding and
management of sepsis. The increasing insight into pathomechanisms of post-infectious …

There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

In North America, approximately 700,000 cases of sepsis occur each year, with mortality
ranging between 30% and 50%. The American Journal of Pathology has featured numerous …

Advances in pathogenesis and management of sepsis : Current Opinion in Infectious Diseases
Advances in pathogenesis and management of sepsis : Current Opinion in Infectious Diseases …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

Abbreviations: ACCP= American College of Chest Physicians; APACHE= acute physiology
and chronic health evaluation; ILl= interleukin 1; iNOS= inducible nitric oxide synthase; …

Our understanding of sepsis and its resultant outcomes remains a paradox. On the one
hand, we know more about the pathophysiology of sepsis than ever before. However, this …

Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of
death in critically ill patients. It is the most common condition with high mortality in intensive …

Introduction: Sepsis is characterized by a dysregulated host response to infection. Sepsis-
associated morbidity/mortality demands concerted research efforts toward therapeutic …

Introduction Sepsis is a complex inflammatory disorder believed to originate from an
infection by any types of microbes and/or their products. It is the leading cause of death in …