Objective Links between pain and joint degradation are poorly understood. We investigated
the role of activation of Toll-like receptors (TLR) by cartilage metabolites in initiating and …

Objective To examine the expression of ADAMTS-7 during the progression of osteoarthritis
(OA), defining its role in the pathogenesis of OA, and elucidating the molecular events …

Tumor necrosis factor (TNF)-α and a disintegrin and metalloproteinase with thrombospondin
motifs 4 (ADAMTS-4) are important in osteoarthritis (OA) cartilage degradation. In the …

Osteoarthritis (OA) is associated with cartilage breakdown, brought about by ADAMTS-5
mediated aggrecan degradation followed by MMP-derived aggrecan and type II collagen …

The aim of the present study is to determine whether ADAMTS-7 contributes to the onset and
severity of joint inflammation in the pathogenesis of inflammatory arthritis. ADAMTS-7 was …

in vivo evidence that ADAMTS-7 has an important role in cartilage and OA development,”
state Yu and Liu. Finally, the molecular pathways involved were investigated. Adamts-7 …

ADAMTS-4 (aggrecanase1) is believed to play an important role in the degradation of
aggrecan during the progression of joint diseases. ADAMTS-4 is synthesized as a latent pro …

Objective To compare induction of the aggrecanases (ADAMTS‐1, ADAMTS‐4, ADAMTS‐5,
ADAMTS‐8, ADAMTS‐9, and ADAMTS‐15) by interleukin‐1β (IL‐1β) and tumor necrosis …

The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family
includes nine members with aggrecan-degrading activity, ie, ADAMTS1, 4, 5, 8, 9, 15, 16 …

Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the
inhibition of metalloproteinases, might be because of their constitutive expression in …