The staphylococcal enterotoxin A (SEA) is a superantigen that must bind to class II
molecules of the major histocompatibility complex to be recognized by T cells. In humans …

Superantigens are thought to make external contacts with major histocompatibility complex
(MHC) class II molecules and with the V beta portion of a T cell antigen receptor (TCR) …

Superantigens bind to MHC class II-positive cells and stimulate T lymphocytes expressing
specific V beta regions of the TCR. Two distinct regions of staphylococcal enterotoxin A …

The superantigen staphylococcal enterotoxin A (SEA) binds to major histocompatibility
complex (MHC) class II molecules at two sites on either side of the peptide groove. Two …

Two binding sites for MHC class II have previously been identified on opposite sides of the
superantigen, staphylococcal enterotoxin A (SEA). The sites mediate separate binding …

A comparative site-directed mutagenesis study of staphylococcal enterotoxins A and B was
undertaken to identify key amino-acid residues which govern interactions with major …

Mutational studies indicate that the superantigen staphylococcal enterotoxin A (SEA) has
two separate binding sites for major histocompatibility complex (MHC) class II molecules …

Multiple binding sites on the staphylococcal enterotoxin A (SEA) molecule which interact
with class II MHC Ag have been suggested by previous studies comparing SEA binding with …

Staphylococcal enterotoxins (SE) and toxic shock syndrome toxin 1 (TSST-1) bind to MHC
class II molecules and the toxin-class II complexes induce proliferation of T cells bearing …

Binding of staphylococcal enterotoxin A (SEA) to MHC class II encoded proteins is a
prerequisite for its subsequent activation of a large fraction of T lymphocytes through …