Observational studies have reported different effects of adiposity on cardiovascular risk
factors across age and sex. Since cardiovascular risk factors are enriched in obese …

Background: Adiposity, as indicated by body mass index (BMI), has been associated with
risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these …

Importance In observational studies, abdominal adiposity has been associated with type 2
diabetes and coronary heart disease (CHD). Whether these associations represent causal …

Background The association between adiposity and cardiometabolic traits is well known
from epidemiological studies. Whilst the causal relationship is clear for some of these traits …

Aims The aim of this study was to investigate the causal relationship and evidence of an
association between increased adiposity and the risk of incident cardiovascular disease …

Aims The data regarding the associations of body mass index (BMI) with cardiovascular
(CVD) risk, especially for those at the low categories of BMI, are conflicting. The aim of our …

Aims/hypothesis Excess adiposity is differentially associated with increased risk of
cardiometabolic disease in men and women, according to observational studies. Causal …

Context Observational studies have suggested associations between adipokines and
cardiovascular disease (CVD), but the roles of certain adipokines remain controversial, and …

Background: The implications of different adiposity measures on cardiovascular disease
etiology remain unclear. In this article, we quantify and contrast causal associations of …

Importance Obesity is associated with a higher risk of cardiovascular disease (CVD), but
little is known about the role that circulating protein biomarkers play in this association …