Natural killer cells as an initial defense against pathogens

MB Lodoen, LL Lanier - Current opinion in immunology, 2006 - Elsevier
Natural killer (NK) cells serve as a crucial first line of defense against tumors and a diverse
range of pathogens. Recognition of infection by NK cells is accomplished by the activation of …

Natural killer cells and viral infections

AR French, WM Yokoyama - Current opinion in immunology, 2003 - Elsevier
Natural killer (NK) cells play a key role in innate host defense against viruses. Significant
progress has been made in understanding the specific response of NK cells during viral …

Regulation of natural killer cell activity

SE Kirwan, DN Burshtyn - Current opinion in immunology, 2007 - Elsevier
Information regarding the role of natural killer (NK) cells in the response to viruses,
intracellular bacteria and parasites continues to emerge. NK cells can directly lyse infected …

Natural killer cells regulate diverse T cell responses

SQ Crome, PA Lang, KS Lang, PS Ohashi - Trends in immunology, 2013 - cell.com
Natural killer (NK) cells are important mediators of the immune response against microbial
pathogens and tumors. There is growing evidence from mouse and human studies that, NK …

Activation of natural killer cells during microbial infections

A Horowitz, KA Stegmann, EM Riley - Frontiers in immunology, 2012 - frontiersin.org
Natural killer (NK) cells are large granular lymphocytes that express a diverse array of
germline encoded inhibitory and activating receptors for MHC Class I and Class I-like …

Signal transduction during activation and inhibition of natural killer cells

C Watzl, EO Long - Current protocols in immunology, 2010 - Wiley Online Library
Natural killer (NK) cells are important for early immune responses to viral infections and
cancer. Upon activation, NK cells secrete cytokines and chemokines, and kill sensitive target …

Natural killer cell responses to viral infection

JD Brandstadter, Y Yang - Journal of innate immunity, 2011 - karger.com
Natural killer (NK) cells, as part of the innate immune system, play a key role in host defense
against viral infections. Recent advances have indicated that NK cell activation and function …

Natural killer (NK) cells in antibacterial innate immunity: angels or devils?

F Souza-Fonseca-Guimaraes, M Adib-Conquy… - Molecular …, 2012 - Springer
Natural killer (NK) cells were first described as immune leukocytes that could kill tumor cells
and soon after were reported to kill virus-infected cells. In the mid-1980s, 10 years after their …

Functions of natural killer cells

E Vivier, E Tomasello, M Baratin, T Walzer… - Nature …, 2008 - nature.com
Natural killer (NK) cells are effector lymphocytes of the innate immune system that control
several types of tumors and microbial infections by limiting their spread and subsequent …

Evolutionary struggles between NK cells and viruses

LL Lanier - Nature Reviews Immunology, 2008 - nature.com
Natural killer (NK) cells are well recognized for their ability to provide a first line of defence
against viral pathogens and they are increasingly being implicated in immune responses …