This volume provides readers a comprehensive and state-of-the-art overview about the
range of applications of targeted therapies for solid tumors. The sections of the book have …

The therapeutic benefits of targeted clinical interventions with increased selectivity and
fewer adverse effects hold great promise in the treatment of solid malignancies, both in …

Many questions remain however unanswered and new challenges appear. Intratumor
heterogeneity emerges as a brake to personalized cancer care. Relevant targets remain …

The rise of targeted therapy for solid tumours over the past decade has yielded a cornucopia
of novel agents across an array of cancers. Amidst multiple acclaimed successes, targeted …

Targeted cancer chemotherapy agents interfere with receptor tyrosine kinase signaling
pathways that promote tumor cell growth. Targeted agents inhibit receptor tyrosine kinase …

It is now exactly 100 years ago (1908) that Paul Ehrlich, who is regarded as the inventor of
the concept of targeted therapy, received the Nobel Prize for Medicine. His initial perception …

New generations of targeted therapies fighting the resistanc... : Current Opinion in Oncology
New generations of targeted therapies fighting the resistance in solid tumors : Current Opinion …

Cancer is a genetic disease arising from somatic mutations in cells that confer a survival
advantage and invasive properties characteristic of the malignant phenotype [1]. The …

The treatment of patients with advanced malignancies has undergone remarkable change in
the last few years. While in the past decisions about systemic therapy were largely based on …

The delineation of signaling pathways to understand tumor biology combined with the rapid
development of technologies that allow broad molecular profiling and data analysis has led …