Symptoms and findings arising from the systemic beta blockade caused by topical ocularly
applied timolol appear shortly after drug application. We studied the systemic absorption of …

Purpose Topical β-blockers, such as timolol, have been used extensively in the medical
treatment of glaucoma to lower intraocular pressure (IOP). Recently, these drugs have been …

Background: Timolol maleate, a nonselective β-adrenoceptor antagonist applied topically to
the eye as a solution, is well known for its ocular hypotensive efficacy. A gellan formulation …

Timolol eyedrops may cause systemic side-effects in glaucoma patients due to absorption of
the drug into systemic circulation. In a previous study, timolol concentrations in plasma were …

Systemic adverse effects of timolol ophthalmic solution given at usual therapeutic doses
have been well characterized. Timolol is partially metabolized by cytochrome P450 (CYP) …

Objectives The aims of the study were to assess the correlation between the plasma
concentration of ophthalmic timolol and cardiovascular parameters, and the influence of …

The absorption of timolol after topical administration to the eye was studied in 11 healthy
volunteers and in 5 patients with bilateral open angle glaucoma. The volunteers received 2 …

Timolol maleate, a nonselective beta blocker, has been associated with adverse reactions
when administered topically or systemically. The current literature pertaining to timolol …

The concentration‐effect relationship of 0.25 mg intravenous timolol with and without
pretreatment with 100 mg quinidine was studied in six healthy young volunteers with a …

Ophthalmic timolol has been used for decades in the treatment of glaucoma and ocular
hypertension, traditionally in aqueous 0.5% eye drops. Recently a timolol 0.1% hydrogel has …