• The effect of topical timolol maleate on exercise performance was investigated in a
randomized double-blind study. Healthy young subjects underwent two graded maximal …

The serum concentrations and β-blockade after dermal application of timolol ointment were
evaluated in six healthy men (21–31 years old; 74–82 kg). Two patches (25 cm 2) containing …

Purpose The purpose of the study was to compare the systemic safety and risk–benefit ratio
of 0.1% timolol hydrogel and 0.5% aqueous timolol eye drops in the treatment of glaucoma …

Synopsis Metipranolol is a non-selective β-adrenoceptor blocking agent used for the topical
treatment of elevated intraocular pressure in patients with chronic open angle glaucoma or …

The literature concerning the clinical and pharmacologic studies of systemically
administered timolol in 2233 patients was reviewed. Side effects reported were correlated …

• Timolol maleate, a β-adrenergic blocking agent, was used in a study of 20 adult patients
with chronic open-angle glaucoma. This single-dose study demonstrated a dose response …

Ocular and cardiovascular effects of carteolol 2%, timolol 0.5%, and dummy eyedrops have
been measured in a single dose double-blind crossover study in six healthy volunteers. Both …

Some lower aliphatic esters of timolol have previously been developed as prodrugs to
potentially diminish the systemic absorption and hence side-effects of topically applied …

We evaluated a topical formulation of timolol in an anionic heteropolysaccharide gellan gum
(Gelrite). Fifty-five white patients with ocular hypertension entered a double-masked …

The O-acetyl, propionyl, butyryl and pivaloyl esters of timolol were synthesized and
evaluated as prodrugs for potential in diminishing the systemic absorption and therefore …