[HTML][HTML] Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells
Synucleinopathies are age-related neurological disorders characterized by the progressive
deposition of α-synuclein (α-syn) aggregates and include Parkinson's disease (PD) and …
deposition of α-synuclein (α-syn) aggregates and include Parkinson's disease (PD) and …
[HTML][HTML] Targeting microglial and neuronal toll-like receptor 2 in synucleinopathies
Synucleinopathies are neurodegenerative disorders characterized by the progressive
accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson's disease …
accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson's disease …
[HTML][HTML] Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and …
C Kim, B Spencer, E Rockenstein, H Yamakado… - Molecular …, 2018 - Springer
Background Synucleinopathies of the aging population are an heterogeneous group of
neurological disorders that includes Parkinson's disease (PD) and dementia with Lewy …
neurological disorders that includes Parkinson's disease (PD) and dementia with Lewy …
[HTML][HTML] Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model
A Sommer, T Fadler, E Dorfmeister… - Journal of …, 2016 - Springer
Background Synucleinopathies comprise a group of neurodegenerative diseases
associated with abnormal accumulation of α-synuclein. One of the key factors that contribute …
associated with abnormal accumulation of α-synuclein. One of the key factors that contribute …
[HTML][HTML] Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models
Background α-Synuclein (α-syn) is a pre-synaptic protein which progressively accumulates
in neuronal and non-neuronal cells in neurodegenerative diseases such as Parkinson's …
in neuronal and non-neuronal cells in neurodegenerative diseases such as Parkinson's …
[HTML][HTML] Alpha-synuclein induced immune cells activation and associated therapy in Parkinson's disease
R Su, T Zhou - Frontiers in aging neuroscience, 2021 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder closely related to immunity. An
important aspect of the pathogenesis of PD is the interaction between α-synuclein and a …
important aspect of the pathogenesis of PD is the interaction between α-synuclein and a …
[HTML][HTML] Peripheral inflammation regulates CNS immune surveillance through the recruitment of inflammatory monocytes upon systemic α-synuclein administration
JM Peralta Ramos, P Iribarren, L Bousset… - Frontiers in …, 2019 - frontiersin.org
Innate immune activation and chronic neuroinflammation are characteristic features of many
neurodegenerative diseases including Parkinson's disease (PD) and may contribute to the …
neurodegenerative diseases including Parkinson's disease (PD) and may contribute to the …
[HTML][HTML] Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α …
S Venezia, V Refolo, A Polissidis, L Stefanis… - Molecular …, 2017 - Springer
Background Alpha-synuclein (α-syn) aggregation represents the pathological hallmark of α-
synucleinopathies like Parkinson's disease (PD), dementia with Lewy bodies (DLB), and …
synucleinopathies like Parkinson's disease (PD), dementia with Lewy bodies (DLB), and …
Alpha-synuclein oligomers impair memory through glial cell activation and via Toll-like receptor 2
P La Vitola, C Balducci, M Cerovic… - Brain, behavior, and …, 2018 - Elsevier
Alpha-synuclein oligomers (α-synOs) are emerging as crucial factors in the pathogenesis of
synucleinopathies. Although the connection between neuroinflammation and α-syn still …
synucleinopathies. Although the connection between neuroinflammation and α-syn still …
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission
EJ Bae, HJ Lee, E Rockenstein, DH Ho… - Journal of …, 2012 - Soc Neuroscience
Abnormal deposition and intercellular propagation of α-synuclein plays a central role in the
pathogenesis of disorders such as Parkinson's Disease (PD) and dementia with Lewy …
pathogenesis of disorders such as Parkinson's Disease (PD) and dementia with Lewy …