A review of the current status of siRNA nanomedicines in the treatment of cancer

P Resnier, T Montier, V Mathieu, JP Benoit, C Passirani - Biomaterials, 2013 - Elsevier
RNA interference currently offers new opportunities for gene therapy by the specific
extinction of targeted gene (s) in cancer diseases. However, the main challenge for nucleic …

Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities

H Isazadeh, F Oruji, S Shabani, J Behroozi… - Molecular Biology …, 2023 - Springer
Advancements in the clinical applications of small interfering RNA (siRNA) in cancer therapy
have opened up new possibilities for precision medicine. siRNAs, as powerful genetic tools …

[HTML][HTML] Nano-formulated siRNA-based therapeutic approaches for cancer therapy

D Jain, SK Prajapati, A Jain, R Singhal - Nano Trends, 2023 - Elsevier
RNAi is a remarkable treatment strategy to knock down gene overexpression in a variety of
disorders, including cancers. RNAi processes allow siRNAs to detect and degrade a …

Nonviral methods for siRNA delivery

K Gao, L Huang - Molecular pharmaceutics, 2009 - ACS Publications
RNA interference (RNAi) as a mechanism to selectively degrade mRNA (mRNA) expression
has emerged as a potential novel approach for drug target validation and the study of …

Advances in siRNA delivery in cancer therapy

A Singh, P Trivedi, NK Jain - Artificial cells, nanomedicine, and …, 2018 - Taylor & Francis
RNA interference (RNAi)-based therapeutic approaches are under vibrant scrutinisation to
seek cancer cure. siRNA suppress expression of the carcinogenic genes by targeting the …

Clinical advances of siRNA-based nanotherapeutics for cancer treatment

D Hattab, AM Gazzali, A Bakhtiar - Pharmaceutics, 2021 - mdpi.com
Cancer is associated with single or multiple gene defects. Recently, much research has
focused on incorporating genetic materials as one of the means to treat various types of …

Nanoparticle‐mediated siRNA delivery systems for cancer therapy

H Gao, R Cheng, H A. Santos - View, 2021 - Wiley Online Library
The small interfering RNA (siRNA)‐based therapeutics have raised great attention since the
first RNA interference (RNAi)‐derived drug, patisiran, was approved by the US Food and …

Recent advancements in the design of nanodelivery systems of siRNA for cancer therapy

DN Yadav, MS Ali, AM Thanekar, SV Pogu… - Molecular …, 2022 - ACS Publications
RNA interference (RNAi) has increased the possibility of restoring RNA drug targets for
cancer treatment. Small interfering RNA (siRNA) is a promising therapeutic RNAi tool that …

Safety profile of RNAi nanomedicines

SA Barros, JA Gollob - Advanced drug delivery reviews, 2012 - Elsevier
The emerging class of RNA interference (RNAi) therapeutics is a fundamentally novel
approach to treating human disease by enabling the pursuit of molecular targets considered …

Tumor‐targeting multifunctional nanoparticles for siRNA delivery: Recent advances in cancer therapy

SH Ku, K Kim, K Choi, SH Kim… - Advanced healthcare …, 2014 - Wiley Online Library
RNA interference (RNAi) is a naturally occurring regulatory process that controls
posttranscriptional gene expression. Small interfering RNA (siRNA), a common form of RNAi …