Detection of acute aortic dissection by extremely high soluble lectin-like oxidized LDL receptor-1 (sLOX-1) and low troponin T levels in blood

N Kobayashi, N Hata, N Kume… - International …, 2013 - internationaljournalofcardiology.com
Acute aortic dissection (AAD) is a potentially critical cardiovascular emergency and would
lead to high mortality without rapid diagnosis and appropriate treatment. D-dimer …

Pioglitazone inhibits LOX-1 expression in human coronary artery endothelial cells by reducing intracellular superoxide radical generation

JL Mehta, B Hu, J Chen, D Li - Arteriosclerosis, thrombosis, and …, 2003 - Am Heart Assoc
Objective—LOX-1, a novel lectin-like receptor for oxidized LDL (ox-LDL), is expressed in
response to ox-LDL, angiotensin II (Ang II), tumor necrosis factor (TNF)-α, and other stress …

Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways

A Akhmedov, GG Camici, MF Reiner… - Cardiovascular …, 2017 - academic.oup.com
Aims The lectin-like oxLDL receptor-1 (LOX-1) promotes endothelial uptake of oxidized low-
density lipoprotein (oxLDL) and plays an important role in atherosclerosis and acute …

LOX-1 abrogation reduces myocardial ischemia–reperfusion injury in mice

C Hu, J Chen, A Dandapat, Y Fujita, N Inoue… - Journal of molecular and …, 2008 - Elsevier
LOX-1 is a newly described lectin-like receptor for oxidized-LDL (ox-LDL), which is over-
expressed in the ischemic myocardium. To examine the pathogenic role of LOX-1 in the …

Role of Ox-LDL and LOX-1 in Atherogenesis

AJ Kattoor, SH Kanuri, JL Mehta - Current medicinal chemistry, 2019 - ingentaconnect.com
Oxidized LDL (ox-LDL) plays a central role in atherosclerosis by acting on multiple cells
such as endothelial cells, macrophages, platelets, fibroblasts and smooth muscle cells …

Activation-dependent surface expression of LOX-1 in human platelets

M Chen, M Kakutani, T Naruko, M Ueda… - Biochemical and …, 2001 - Elsevier
Lectin-like oxidized LDL receptor-1 (LOX-1) was initially identified as an oxidized LDL
receptor in aortic endothelial cells. Here we identified LOX-1 mRNA and protein in human …

Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions

H Kataoka, N Kume, S Miyamoto, M Minami… - Circulation, 1999 - Am Heart Assoc
Background—Oxidized LDL (Ox-LDL) seems to play key roles in atherogenesis. Lectinlike
Ox-LDL receptor-1 (LOX-1) is a recently identified cell-surface receptor for Ox-LDL. The …

Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1)

H Mitsuoka, N Kume, K Hayashida, A Inui-Hayashiada… - Atherosclerosis, 2009 - Elsevier
Lectin-like oxidized LDL receptor-1 (LOX-1) appears to play crucial roles in atherosclerotic
plaque rupture. We previously reported that circulating soluble LOX-1 (sLOX-1) levels are …

LOX‐1, OxLDL, and atherosclerosis

A Pirillo, GD Norata, AL Catapano - Mediators of inflammation, 2013 - Wiley Online Library
Oxidized low‐density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation
and progression by several mechanisms, including the induction of endothelial cell …

Significance of soluble lectin‐like oxidized LDL receptor‐1 levels in systemic and coronary circulation in acute coronary syndrome

T Misaka, S Suzuki, N Sakamoto… - BioMed research …, 2014 - Wiley Online Library
Background. Soluble lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1) level is
a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in …