The molecular links between inflammation and coagulation are unquestioned. Inflammation
promotes coagulation by leading to intravascular tissue factor expression, eliciting the …

After a coagulation stimulus, the blood clotting cascade amplifies largely unchecked until
very high levels of thrombin are generated. Natural anticoagulant mechanisms (for example …

Inflammation contributions to the thrombotic response involve both cellular and humoral
modulation. Inflammation impacts the initiation, propagation and the inhibitory phases of …

The protein C pathway plays a critical role in the negative regulation of the blood clotting
process. We recently identified an endothelial cell receptor for protein C/activated protein C …

Objective: To review new findings about the function of the protein C system during
inflammation and coagulation. Main Findings: Coagulation proteases and their cofactors …

The protein C pathway is a primary regulator of blood coagulation and a critical component
of the host response to inflammatory stimuli. The most recent member of this pathway is the …

Endothelial cell protein C receptor (EPCR) was first identified and isolated as a cellular
receptor for protein C on endothelial cells. EPCR plays a crucial role in the protein C …

The endothelial cell protein C receptor@ PCR) is the most recently identified member O {,
the protein C anticoagulant pathway. Protein C and activaibd protein C (APC) bind to EPCR …

The protein C anticoagulant pathway serves as a major system for controlling thrombosis,
limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in …

Thrombin is a multifunctional protein, with procoagulant, inflammatory and anticoagulant
effects. Binding of thrombin to thrombomodulin results in activation of Protein C and initiation …