The decline of cognitive function has emerged as one of the greatest health threats of old
age. Age-related cognitive decline is caused by an impacted neuronal circuitry, yet the …

The complement system is part of the innate immune response responsible for removing
pathogens and cellular debris, in addition to helping to refine CNS neuronal connections via …

Neuroimmune interactions mediate intercellular communication and underlie critical brain
functions. Microglia, CNS-resident macrophages, modulate the brain through direct physical …

The innate immune system is an ancient and primary component system that rapidly reacts
to defend the body against external pathogens. C1 is the initial responder of classical …

J. Neurochem.(2010) 112, 733–743. Abstract The expression of C1q, a recognition molecule
of the complement system, is up‐regulated following neuronal injury and is detected early in …

Background The complement cascade not only provides protection from infection but can
also mediate destructive inflammation. Complement is also involved in elimination of …

C1q, the recognition component of the classical complement activation pathway, is a
multifunctional protein known to be expressed in brain of Alzheimer's disease (AD) patients …

Activation of the complement cascade, a powerful effector mechanism of the innate immune
system, is associated with neuroinflammation but also with elimination of inappropriate …

Alzheimer's disease (AD) is a neurodegenerative disease resulting in progressive cognitive
decline. Amyloid plaque deposits consisting specifically of β‐amyloid peptides that have …

Background Cognitive impairment in schizophrenia, aging, and Alzheimer's disease is
associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer …