Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic
liver diseases, including hepatocellular carcinoma (HCC). The HBV encoded proteins …

Introduction: Oxidative stress underlies the pathophysiology of various etiologies of chronic
liver disease and contributes to the development of hepatocarcinogenesis. Areas covered …

Accumulating evidence has indicated that oxidative stress (OS) is associated with the
development of hepatocellular carcinoma (HCC). However, the mechanisms remain largely …

Virally induced liver cancer usually evolves over long periods of time in the context of a
strongly oxidative microenvironment, characterized by chronic liver inflammation and …

The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …

A complex antioxidant system has been developed in mammals to relieve oxidative stress.
However, excessive reactive species derived from oxygen and nitrogen may still lead to …

Hepatitis C virus (HCV) is a blood-borne pathogen that was identified as an etiologic agent
of non-A, non-B hepatitis in 1989. HCV is estimated to have infected at least 170 million …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths
worldwide. There are two major challenges for HCC, the first being that early detection is …

Oxidative stress is a common pathogenetic mechanism contributing to initiation and
progression of hepatic damage in a variety of liver disorders. Cell damage occurs when …

The crucial roles of oxidative stress and inflammation in the development of hepatic
diseases have been unraveled and emphasized for decades. From steatosis to fibrosis …