In order to determine if post-mortem delays could account for the apparent absence of 5-HT
1B sites reported in human brain, 5-HT 1B binding parameters were determined in fresh and …

The first proposal to formally establish the 5-HT 1 class of binding sites occurred when
Peroutka and Snyder (1979) determined that [3 H] LSD labeled two distinct populations of …

The presence, pharmacological properties and anatomical distribution of serotonin-1A and
serotonin-1B receptor subtypes were studied in the human brain by both radioligand binding …

Two distinct serotonin receptors in mammalian brain are labeled respectively with [3 H]
serotonin (5-HT 1) and [3 H] spiperone (5-HT 2). In general, agonists display highest …

In the presence of 1 μM (±)‐pindolol [to block 5‐hydroxytryptamine (5‐HT, serotonin) 5‐
HT1A and 5‐HT1B receptors] and 100 nM mesulergine (to block 5‐HT1C receptors), 2.0 nM …

This report describes the pharmacologic characterization of [3 H] serotonin binding activity
solubilized from bovine frontal cortical membranes. The ability of a number of serotonin (5 …

MATTERS ARISING 317 vious claims that the 5-HT2 receptor is a two-state receptor were
correct, then both states should be demonstrable in any tissue containing the radiolabeled 5 …

Serotonin,(5‐hydroxytryptamine1, 5‐HT1) binding sites have been solubilized from bovine
brain cortex using a mixture of 0.1% Nonidet P‐40 and 0.3% digitonin in a low‐salt buffer …

Soon after the development of binding assays using [3H] 5-hydroxytryptamine (['H] 5-HT) to
label the specific recognition sites for serotonin on membranebound receptors in the central …

Serotonin (5HT) binding sites in the medulla oblongata of the rat were localized using
autoradiographic techniques with radioactive ligands that express high affinity for the …