Gene transfer to animal cells was first achieved more than thirty years ago. Since then,
transformation technology has developed rapidly, resulting in a multitude of techniques for …

During the past decade, a series of scientific advances have provided the opportunity for the
modification of domestic animals in a way that has never before been possible—that is, the …

Gene transfer technology provides the ability to genetically manipulate the cells of higher
animals. Gene transfer permits both germline and somatic alterations. Such genetic …

Gene transfer to generate transgenic animals is used more and more to study gene
regulation and function. It is also an essential tool to prepare pharmaceuticals or pig organs …

The development of methods for cell‐mediated transgenesis, based on somatic cell nuclear
transfer, provides a tremendous opportunity to shape the genetic make‐up of livestock …

Transgenic animals continue to embody one of the most potent and exciting research tools
in the biological sciences. Transgenic animals represent unique models that are custom …

One of the major challenges currently facing the scientific community is to understand the
function of the 20,000–25,000 protein-coding genes that were revealed when the human …

In contrast to the highly developed genetic modification systems available for manipulating
the mouse genome, at this time only simple gain of function modifications can be undertaken …

Transgenic animal technologies and the ability to introduce functional genes into animals
have revolutionized our ability to address complex biomedical and biological questions. This …

Position effects in animal transgenesis have prevented the reproducible success and limited
the initial expectations of this technique in many biotechnological projects. Historically …