Insights into the source, mechanism and biotechnological applications of hyaluronidases

YS Zhang, JS Gong, ZY Yao, JY Jiang, C Su, H Li… - Biotechnology …, 2022 - Elsevier
It has long been found that hyaluronidases exist in a variety of organisms, playing their roles
in various biological processes including infection, envenomation and metabolic regulation …

Enzymatic production of low-molecular-weight hyaluronan and its oligosaccharides: A review and prospects

B Pang, H Wang, H Huang, L Liao… - Journal of Agricultural …, 2022 - ACS Publications
Hyaluronic acid (HA) is a nonsulfated linear glycosaminoglycan with a negative charge.
Different from the high-molecular-weight HAs, the low-molecular-weight HAs (LMW-HAs, 4 …

Hyaluronidases and hyaluronate lyases: From humans to bacteriophages

M Sindelar, J Jilkova, L Kubala, V Velebny… - Colloids and Surfaces B …, 2021 - Elsevier
Hyaluronan is a non-sulfated negatively-charged linear polymer distributed in most parts of
the human body, where it is located around cells in the extracellular matrix of connective …

The magic glue hyaluronan and its eraser hyaluronidase: a biological overview

KS Girish, K Kemparaju - Life sciences, 2007 - Elsevier
Hyaluronan (HA) is a multifunctional high molecular weight polysaccharide found
throughout the animal kingdom, especially in the extracellular matrix (ECM) of soft …

Identification and characterization of a bacterial hyaluronidase and its production in recombinant form

L Messina, JA Gavira, S Pernagallo… - FEBS …, 2016 - Wiley Online Library
Hyaluronidases (Hyals) are broadly used in medical applications to facilitate the dispersion
and/or absorption of fluids or medications. This study reports the isolation, cloning, and …

Clinical applications of hyaluronidase

GC Weber, BA Buhren, H Schrumpf, J Wohlrab… - … Enzymes: Function and …, 2019 - Springer
Hyaluronidases are enzymes that degrade hyaluronic acid, which constitutes an essential
part of the extracellular matrix. Initially discovered in bacteria, hyaluronidases are known to …

Hyaluronidases in human diseases

A Kaul, WD Short, X Wang, SG Keswani - International Journal of …, 2021 - mdpi.com
With the burgeoning interest in hyaluronic acid (HA) in recent years, hyaluronidases
(HYALs) have come to light for their role in regulating catabolism of HA and its molecular …

[PDF][PDF] Property and current clinical applications of mammal hyaluronidase.

SH Lv, SF Rong, BG Cai, SM Guan - European Review for …, 2015 - europeanreview.org
Art. 1.1475/ringraziamenti Page 1 European Review for Medical and Pharmacological
Sciences 3968 Abstract. – Hyaluronidase (Hyal), which is related to mammalian diseases …

Hyaluronidase reaction kinetics evaluated by capillary electrophoresis with UV and high-resolution mass spectrometry (HRMS) detection

S Fayad, R Nehmé, M Langmajerová, B Ayela… - Analytica chimica …, 2017 - Elsevier
The biology of hyaluronidase activity on age related turnover of the hyaluronic acid (HA) in
skin dermis and epidermis has not been established. Elucidation of this phenomenon …

Hyaluronidases: their genomics, structures, and mechanisms of action

R Stern, MJ Jedrzejas - Chemical reviews, 2006 - ACS Publications
The hyaluronidases (Hyals) are classes of enzymes that degrade, predominantly,
hyaluronan (HA). The term “hyaluronidase” is somewhat of a misnomer since they have the …