Hereditary spastic paraplegia (HSP) is characterized by progressive lower limb spasticity.
There is no disease-modifying treatment currently available. Therefore, standardized …

The term hereditary spastic paraplegia (HSP) embraces a clinically and genetically
heterogeneous group of neurodegenerative diseases characterized by progressive …

Background Hereditary spastic paraplegia (HSP) is a group of inherited disorders
characterized by progressive spastic paresis of the lower limbs. Treatment is often focused …

Background Hereditary spastic paraplegia (HSP) is a rare genetic disorder associated with
mutations in> 80 loci designated SPG (SPastic parapleGia). The phenotypic spectrum of …

Hereditary spastic paraplegias (HSPs) are a large group of genetically-diverse neurologic
disorders characterized clinically by a common feature of lower extremity spasticity and gait …

Introduction Hereditary spastic paraplegias (HSP) include a clinically and genetically
heterogeneous group of conditions. Novel imaging modalities have been increasingly …

Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic
neurodegenerative diseases characterised by progressive spasticity of the lower limbs. The …

Abstract Purpose of Review The hereditary spastic paraplegias (HSPs) are a group of
disorders characterised by progressive lower limb weakness and spasticity. We address the …

Background We aimed to identify healthcare needs, expectations, utilization, and the
experienced treatment effects in a population of Dutch patients with hereditary spastic …

Progressive spasticity and gait impairment is the functional hallmark of hereditary spastic
paraplegia (HSP), but due to inter‐individual variability, longitudinal studies on its …