Significant progress has been made recently in the understanding of cell adhesion
signaling. Many components of focal adhesion complexes have been identified in fibroblasts …

The growth and differentiation of hematopoietic stem cells are highly dependent on
regulatory molecules produced by stromal cells of the marrow environment. Evidence has …

HEMATOPOIESIS IS A complex process in which pluripo-tent stem cells proliferate and
differentiate to generate the full complement of mature blood cells. More than 30 …

In the adult mammal, haemopoiesis is restricted to the extravascular compartment of the
bone marrow (BM) where primitive haemopoietic stem cells (HSC) and their clonogenic …

Normal steady-state hematopoiesis takes place in the bone marrow microenvironment.
Soluble factors as well as contact interactions between the hematopoietic cells and the …

Abstract Here, Martin Hemler focuses on the emerging field of hematopooetic cell adhesion
to extracellular matrix. Analysis of newly discovered receptor structures involved in cell …

Adhesion of hematopoietic progenitor cells to marrow-derived adherent cells has been
noted for erythroid, myeloid, and lymphoid precursors. In this report, we have characterized …

The mechanisms by which hematopoietic progenitor cells are normally anchored in stromal
niches and yet can be mobilized by specific growth factors are poorly understood. It is likely …

Hematopoietic progenitor cells are incubated with cytokine combinations for in vitro
expansion of stem cells and to enhance retrovirus-mediated gene transfer. Optimization of …

Close interaction of human hematopoietic progenitors with the bone marrow
microenvironment is important for the ordered progression of human hematopoiesis …