Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and
clinicians and are a tremendous burden for health-care systems. Despite extensive basic …

Introduction Sepsis is a complex inflammatory disorder believed to originate from an
infection by any types of microbes and/or their products. It is the leading cause of death in …

Sepsis is an ill-defined syndrome yet is a leading cause of morbidity and mortality
worldwide. The most recent consensus defines sepsis as life-threatening organ dysfunction …

Sepsis and septic shock lead to considerable morbidity and mortality in developed and
developing countries. Despite advances in understanding the innate immune events that …

Sepsis can be seen as a PRR-mediated dysregulation of the immune system following
pathogen invasion in which a careful balance between inflammatory and anti-inflammatory …

Sepsis is characterized as a life-threatening organ dysfunction syndrome that is caused by a
dysregulated host response to infection. The main etiological causes of sepsis are bacterial …

Sepsis is expected to have a substantial impact on public health and cost as its prevalence
increases. Factors contributing to increased prevalence include a progressively aging …

The clinical syndrome of sepsis encompasses a highly heterogeneous group of clinical
disorders, varying with respect to the site, bacteriology, and even presence of infection and …

Sepsis–the most common cause of death in hospitalized patients–affects over 18 million
people worldwide and has an expected 1% increase of incidence per year. Recent clinical …

Sepsis is a clinical syndrome that results from a systemic host response to an infection. The
outcome of sepsis is poor, and mortality rates are as high as 30–40%. Sepsis is associated …