Sepsis is a significant cause of death worldwide. Although the prevailing theory of the sepsis
syndrome has been that of a condition of uncontrolled inflammation in response to infection …

Background: The past several years have seen remarkable advances in understanding the
basic cellular and physiologic mechanisms underlying organ dysfunction and recovery …

Strategies for blocking the systemic effects of cytokines in... : Critical Care Medicine Strategies
for blocking the systemic effects of cytokines in the sepsis syndrome : Critical Care Medicine …

Over the past two decades, it has become well accepted that sepsis exhibits two, oftentimes
concomitant, inflammatory stages; a pro-inflammatory phase, referred to as the systemic …

The last two to three years provided several “big steps” regarding our understanding and
management of sepsis. The increasing insight into pathomechanisms of post-infectious …

The sepsis syndrome is characterized by the acute release of a variety of inflammatory
mediators, which often result in detrimental effects to the host. The release of these …

Sepsis is a complex condition characterized by the simultaneous activation of inflammation
and coagulation in response to microbial insult. These events manifest as systemic …

Dear Editor, Septic shock and the underlying dysregulated inflammatory host-response
remain major contributors to mortality in critically ill patients. In contrast to classic …

Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …

Sepsis is one of the leading causes of deaths world-wide and yet there are no therapies
available other than ICU treatment. The patient outcome is determined by a complex …