Plasma proteome in multiple sclerosis disease progression

A Malekzadeh, C Leurs… - Annals of clinical …, 2019 - Wiley Online Library
Background The pathophysiology of multiple sclerosis disease progression remains
undetermined. The aim of this study was to identify differences in plasma proteome during …

Label-free Quantitative Proteomic Analysis of Cerebrospinal Fluid and Serum in Patients With Relapse-Remitting Multiple Sclerosis

H Liu, Z Wang, H Li, M Li, B Han, Y Qi, H Wang… - Frontiers in …, 2022 - frontiersin.org
Background: The lack of effective serum and cerebrospinal fluid (CSF) biomarkers remains a
barrier to early diagnosis and treatment of multiple sclerosis (MS). The study is to identify the …

Serum proteomics in multiple sclerosis disease progression

H Tremlett, DLY Dai, Z Hollander, A Kapanen, T Aziz… - Journal of …, 2015 - Elsevier
Multiple sclerosis (MS) is associated with chronic degeneration of the central nervous
system and may cause permanent neurological problems and considerable disability. While …

Inflammatory and neurodegenerative serum protein biomarkers increase sensitivity to detect clinical and radiographic disease activity in multiple sclerosis

T Chitnis, F Qureshi, VM Gehman, M Becich… - Nature …, 2024 - nature.com
The multifaceted nature of multiple sclerosis requires quantitative biomarkers that can
provide insights related to diverse physiological pathways. To this end, proteomic analysis of …

Cerebrospinal fluid proteome comparison between multiple sclerosis patients and controls

AC Kroksveen, A Guldbrandsen… - Acta Neurologica …, 2012 - Wiley Online Library
Objectives The aim of the present study was to identify proteins in cerebrospinal fluid (CSF)
with different abundance between patients with relapsing‐remitting multiple sclerosis …

Quantitative proteomic analysis of the cerebrospinal fluid of patients with multiple sclerosis

S Liu, S Bai, Z Qin, Y Yang, Y Cui… - Journal of cellular and …, 2009 - Wiley Online Library
The diagnosis of multiple sclerosis (MS) is challenging for the lack of a specific diagnostic
test. Recent researches in quantitative proteomics, however, offer new opportunities for …

Proteomic analysis of cerebrospinal fluid for relapsing-remitting multiple sclerosis and clinically isolated syndrome

Z Pavelek, O Vyšata, V Tambor… - Biomedical …, 2016 - spandidos-publications.com
Early diagnosis and treatment of multiple sclerosis (MS) in the initial stages of the disease
can significantly retard its progression. The aim of the present study was to identify changes …

Proteomic signatures of physical, cognitive, and imaging outcomes in multiple sclerosis

K Jalaleddini, D Jakimovski, A Keshavan… - Annals of Clinical …, 2024 - Wiley Online Library
Background A quantitative measurement of serum proteome biomarkers that would
associate with disease progression endpoints can provide risk stratification for persons with …

Serum proteomic analysis of a pre‐symptomatic multiple sclerosis cohort

MT Wallin, U Oh, J Nyalwidhe… - European Journal of …, 2015 - Wiley Online Library
Background and purpose Susceptibility to multiple sclerosis (MS) is determined by
environmental and genetic factors, but the cause remains unknown. Changes to the …

Discovery of novel biomarkers for diagnosing and predicting the progression of multiple sclerosis using TMT-based quantitative proteomics

Y Shi, Y Ding, G Li, L Wang, RA Osman, J Sun… - Frontiers in …, 2021 - frontiersin.org
Objective Here, we aimed to identify protein biomarkers that could rapidly and accurately
diagnose multiple sclerosis (MS) using a highly sensitive proteomic immunoassay. Methods …