Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …

Depression is the most common type of neuropsychiatric illness and has increasingly
become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 …

Though a great many of studies on the development of antidepressants for the therapy of
major depression disorder (MDD) and the development of antidepressants have been …

Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human
diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse …

Sigma receptors comprise a unique family of proteins that have been implicated in the
pathophysiology and treatment of many central nervous system disorders, consistent with …

Despite the widespread and devastating impact of depression on society, our current
understanding of its pathogenesis is limited. Likewise, existing treatments are inadequate …

Originally considered an enigmatic protein, the sigma-1 receptor has recently been
identified as a unique ligand-regulated molecular chaperone in the endoplasmic reticulum …

Sigma () receptors hove long been implicated in a variety of neuronal and brain functions,
although their precise biochemical and physiolog ical role, and potential involvement in …

Sigma-2 receptor is a widely distributed protein, which can modulate cell proliferation and
involved in the pathogenesis of tumor. Photoaffinity labelling techniques testified that its …

Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited
data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present …