[HTML][HTML] Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders
K Sałaciak, K Pytka - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …
Sigma-1 receptors in depression: mechanism and therapeutic development
P Ren, J Wang, N Li, G Li, H Ma, Y Zhao… - Frontiers in …, 2022 - frontiersin.org
Depression is the most common type of neuropsychiatric illness and has increasingly
become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 …
become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 …
Sigma-1 receptor: A potential target for the development of antidepressants
YM Wang, CY Xia, HM Jia, J He, WW Lian… - Neurochemistry …, 2022 - Elsevier
Though a great many of studies on the development of antidepressants for the therapy of
major depression disorder (MDD) and the development of antidepressants have been …
major depression disorder (MDD) and the development of antidepressants have been …
[HTML][HTML] Sigma-1 receptor: the novel intracellular target of neuropsychotherapeutic drugs
T Hayashi - Journal of pharmacological sciences, 2015 - Elsevier
Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human
diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse …
diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse …
Sigma receptors as potential therapeutic targets for neuroprotection
Sigma receptors comprise a unique family of proteins that have been implicated in the
pathophysiology and treatment of many central nervous system disorders, consistent with …
pathophysiology and treatment of many central nervous system disorders, consistent with …
Sigma receptors: potential targets for a new class of antidepressant drug
JA Fishback, MJ Robson, YT Xu… - Pharmacology & …, 2010 - Elsevier
Despite the widespread and devastating impact of depression on society, our current
understanding of its pathogenesis is limited. Likewise, existing treatments are inadequate …
understanding of its pathogenesis is limited. Likewise, existing treatments are inadequate …
The pharmacology of sigma-1 receptors
T Maurice, TP Su - Pharmacology & therapeutics, 2009 - Elsevier
Originally considered an enigmatic protein, the sigma-1 receptor has recently been
identified as a unique ligand-regulated molecular chaperone in the endoplasmic reticulum …
identified as a unique ligand-regulated molecular chaperone in the endoplasmic reticulum …
[PDF][PDF] The sigma-1 receptor and its role in the treatment of mood disorders
T Hayashi, SM Stahl - Drugs Future, 2009 - researchgate.net
Sigma () receptors hove long been implicated in a variety of neuronal and brain functions,
although their precise biochemical and physiolog ical role, and potential involvement in …
although their precise biochemical and physiolog ical role, and potential involvement in …
Sigma-2 receptor ligands: neurobiological effects
L Guo, X Zhen - Current medicinal chemistry, 2015 - ingentaconnect.com
Sigma-2 receptor is a widely distributed protein, which can modulate cell proliferation and
involved in the pathogenesis of tumor. Photoaffinity labelling techniques testified that its …
involved in the pathogenesis of tumor. Photoaffinity labelling techniques testified that its …
Sigma-1 receptor knockout mice display a depressive-like phenotype
Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited
data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present …
data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present …