C3 exoenzyme from Clostridium botulinum, specifically ADP-ribosylates small GTP-binding
proteins RhoA, B, and C. ADP-ribosylation causes functional inactivation of Rho proteins …

C3 exoenzyme from Clostridium botulinum is the prototype of bacterial ADP-
ribosyltransferases, which selectively modifies the Rho isoforms RhoA, RhoB and RhoC by …

C3 from Clostridium botulinum (C3) specifically modifies Rho GTPases RhoA, RhoB, and
RhoC by mono-ADP-ribosylation. The confined substrate profile of C3 is the basis for its use …

Clostridium botulinum C3 ADP-ribosyltransferase (botulinum C3 exoenzyme) is an
exoenzyme which is produced as a single polypeptide of about 23 kDa by Clostridium …

J. Neurochem.(2012) 120, 1084–1096. Abstract C3 ADP‐ribosyltransferase is a valuable
tool to study Rho‐dependent cellular processes. In the current study we investigated the …

Various bacterial protein toxins and exoenzymes interfere with target cell functions by
catalyzing posttranslational modification of eukaryoticmaster regulators'. Studies from recent …

Publisher Summary This chapter describes the in vitro ADP-ribosylation reaction, the
purification of the C3 exoenzyme, and the application of the C3 exoenzyme in biological …

C3-like exoenzymes are produced by various microorganism including Clostridium
botulinum (C3bot), Bacillus cereus and Staphylococcus aureus. C3bot is the prototype of C3 …

The Rho family of small GTP-binding proteins functions to regulate the assembly of distinct
actin structures in cells; Rho regulates stress fiber assembly, Rac regulates lamellipodia …

The influence of sodium dodecyl sulfate (SDS) on ADP-ribosylation by Clostridium
botulinum C3 exoenzyme (C3) was studied. SDS increased the ADP-ribosylation of …