It is acknowledged that cancer cells are able to undergo senescence in response to
clinically used chemotherapeutics. Moreover, recent years have provided evidence that …

Cellular senescence is the state of permanent proliferation cessation. There are two types of
cell senescence. One is replicative senescence, which relies on telomere length-dependent …

Cellular senescence process results in stable cell cycle arrest, which prevents cell
proliferation. It can be induced by a variety of stimuli including metabolic stress, DNA …

Cellular senescence is a state of stable cell-cycle arrest with secretory features in response
to cellular stress. Historically, it has been considered as an endogenous evolutionary …

Cell senescence is a process that occurs due to telomere erosion or can be induced by
various stresses. Senescent cells cease to divide but remain alive, metabolically active and …

In contrast to the well-recognized replicative and stress-induced premature senescence of
normal somatic cells, mechanisms and clinical implications of senescence of cancer cells …

Colorectal cancer (CRC) is the second leading cause of death among cancer patients in the
Northern countries. CRC can reappear a long time after treatment. Recent clinical studies …

H460 non-small cell lung, HCT116 colon and 4T1 breast tumor cell lines induced into
senescence by exposure to either etoposide or doxorubicin were able to recover …

Recently, it has been shown that oncogene-induced senescence (OIS) occurs during the
early stages of tumorigenesis. Senescent tumour cells are abundant within premalignant …

Abstract Therapy-Induced Senescence (TIS) is an established response to anticancer
therapy in a variety of cancer models. Ample evidence has characterized the triggers …