Diversity of the senescence phenotype of cancer cells treated with chemotherapeutic agents
A Bojko, J Czarnecka-Herok, A Charzynska… - Cells, 2019 - mdpi.com
It is acknowledged that cancer cells are able to undergo senescence in response to
clinically used chemotherapeutics. Moreover, recent years have provided evidence that …
clinically used chemotherapeutics. Moreover, recent years have provided evidence that …
Morphological and functional characteristic of senescent cancer cells
E Sikora, G Mosieniak… - Current drug targets, 2016 - ingentaconnect.com
Cellular senescence is the state of permanent proliferation cessation. There are two types of
cell senescence. One is replicative senescence, which relies on telomere length-dependent …
cell senescence. One is replicative senescence, which relies on telomere length-dependent …
Senescence of tumor cells in anticancer therapy—Beneficial and detrimental effects
WM Piskorz, M Cechowska-Pasko - International journal of molecular …, 2022 - mdpi.com
Cellular senescence process results in stable cell cycle arrest, which prevents cell
proliferation. It can be induced by a variety of stimuli including metabolic stress, DNA …
proliferation. It can be induced by a variety of stimuli including metabolic stress, DNA …
Cellular senescence in cancer: clinical detection and prognostic implications
Cellular senescence is a state of stable cell-cycle arrest with secretory features in response
to cellular stress. Historically, it has been considered as an endogenous evolutionary …
to cellular stress. Historically, it has been considered as an endogenous evolutionary …
[PDF][PDF] What is and what is not cell senescence
E Sikora, A Bielak-Żmijewska, G Mosieniak - Postepy Biochem, 2018 - researchgate.net
Cell senescence is a process that occurs due to telomere erosion or can be induced by
various stresses. Senescent cells cease to divide but remain alive, metabolically active and …
various stresses. Senescent cells cease to divide but remain alive, metabolically active and …
Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cells
J Mikuła-Pietrasik, A Niklas, P Uruski, A Tykarski… - Cellular and Molecular …, 2020 - Springer
In contrast to the well-recognized replicative and stress-induced premature senescence of
normal somatic cells, mechanisms and clinical implications of senescence of cancer cells …
normal somatic cells, mechanisms and clinical implications of senescence of cancer cells …
Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features
H Was, J Czarnecka, A Kominek, K Barszcz… - Cancer biology & …, 2018 - Taylor & Francis
Colorectal cancer (CRC) is the second leading cause of death among cancer patients in the
Northern countries. CRC can reappear a long time after treatment. Recent clinical studies …
Northern countries. CRC can reappear a long time after treatment. Recent clinical studies …
Tumor cell escape from therapy-induced senescence
T Saleh, L Tyutyunyk-Massey, GF Murray… - Biochemical …, 2019 - Elsevier
H460 non-small cell lung, HCT116 colon and 4T1 breast tumor cell lines induced into
senescence by exposure to either etoposide or doxorubicin were able to recover …
senescence by exposure to either etoposide or doxorubicin were able to recover …
The power and the promise of oncogene-induced senescence markers
Recently, it has been shown that oncogene-induced senescence (OIS) occurs during the
early stages of tumorigenesis. Senescent tumour cells are abundant within premalignant …
early stages of tumorigenesis. Senescent tumour cells are abundant within premalignant …
Therapy-induced senescence as a component of tumor biology: Evidence from clinical cancer
T Saleh, S Bloukh, M Hasan, S Al Shboul - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract Therapy-Induced Senescence (TIS) is an established response to anticancer
therapy in a variety of cancer models. Ample evidence has characterized the triggers …
therapy in a variety of cancer models. Ample evidence has characterized the triggers …
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