Molecular links between endothelial dysfunction and neurodegeneration in Alzheimer's disease

E Lyros, C Bakogiannis, Y Liu… - Current Alzheimer …, 2014 - ingentaconnect.com
Alzheimer's disease (AD) is characterized by a progressive decline of cognitive functions
and represents the most common form of dementia and a major cause of morbidity and …

Endothelial dysfunction and repair in Alzheimer-type neurodegeneration: neuronal and glial control

AB Salmina, AI Inzhutova… - Journal of …, 2010 - content.iospress.com
Current theories state that Alzheimer's disease (AD) is a vascular disorder that initiates its
pathology through cerebral microvascular abnormalities. Endothelial dysfunction caused by …

Endothelial dysfunction and amyloid-β-induced neurovascular alterations

K Koizumi, G Wang, L Park - Cellular and molecular neurobiology, 2016 - Springer
Alzheimer's disease (AD) and cerebrovascular diseases share common vascular risk factors
that have disastrous effects on cerebrovascular regulation. Endothelial cells, lining inner …

Vascular dysfunction in the pathogenesis of Alzheimer's disease—A review of endothelium-mediated mechanisms and ensuing vicious circles

LY Di Marco, A Venneri, E Farkas, PC Evans… - Neurobiology of …, 2015 - Elsevier
Late-onset dementia is a major health concern in the ageing population. Alzheimer's
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …

Vascular dysfunction in Alzheimer's disease: a biomarker of disease progression and a potential therapeutic target

K Govindpani, C Vinnakota, HJ Waldvogel… - Neural regeneration …, 2020 - journals.lww.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the predominant
form of dementia. Since its initial description by Alois Alzheimer in 1906, several advances …

Vascular factors and epigenetic modifications in the pathogenesis of Alzheimer's disease

J Leszek, M Sochocka, K Gąsiorowski - Journal of the neurological …, 2012 - Elsevier
Alzheimer's disease (AD) is a debilitating illness with no known cure. Nowadays
accumulating evidence suggested that the vascular endothelium and chronic hypoperfusion …

The imbalance of vascular molecules in Alzheimer's disease

RD Bell - Journal of Alzheimer's Disease, 2012 - content.iospress.com
The vascular system plays an integral role during Alzheimer's disease (AD). Both systemic
circulatory changes and alterations directly within the brain vasculature have been …

Biomarkers assessing endothelial dysfunction in Alzheimer's Disease

A Custodia, M Aramburu-Núñez… - Cells, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common degenerative disorder in the elderly in
developed countries. Currently, growing evidence is pointing at endothelial dysfunction as a …

[HTML][HTML] Dementia: Alzheimer pathology and vascular factors: from mutually exclusive to interaction

AGW van Norden, EJ van Dijk, KF de Laat… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia. Both its incidence and
prevalence are expected to increase exponentially as populations' age worldwide. Despite …

Microvascular Contributions to Alzheimer Disease Pathogenesis: Is Alzheimer Disease Primarily an Endotheliopathy?

R Tarawneh - Biomolecules, 2023 - mdpi.com
Alzheimer disease (AD) models are based on the notion that abnormal protein aggregation
is the primary event in AD, which begins a decade or longer prior to symptom onset, and …