The effect on blood pressure and heart rate, following administration of the same
intracerebroventricular (ivt) and intravenous (iv) doses of captopril, was compared in freely …

1. The hypotensive response to captopril in anaesthetized spontanously hypertensive rats
(SHR) is not modified by bilateral nephrectomy performed 1 or 24 h previously. 2 …

Previous studies from our laboratory have shown that chronic intracerebroventricular
administration of captopril attenuates the development of hypertension in the spontaneously …

An orally active inhibitor of the enzyme that converts angiotensin I to angiotensin II (All) and
degrades bradykinin has recently been shown to lower blood pressure in spontaneously …

These experiments were designed to test the hypothesis that the antihypertensive action of
the converting enzyme inhibitor captopril in conscious spontaneously hypertensive rats is …

In conscious spontaneously hypertensive rats, intraxerebroventricular injection of captopril
(2 mg/kg) resulted in a rapid hypotensive response that lasted several hours. The same …

In conscious, unrestrained spontaneously hypertensive rats (SHR), mean arterial blood
pressure (MAP) increased from a pretreatment value of 150+/-4 to 179+/-7mm Hg within 10 …

The effects of captopril and angiotensin II on adrenergic neurotransmission have been
studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). In a pithed …

Captopril infused into the lateral ventricle (ICV) of adult spontaneously hypertensive rats
(SHR) decreases blood pressure. The current study was designed to explore the effects of …

The ability of centrally administered angiotensin converting enzyme (ACE) inhibitors to lower
mean arterial pressure (MAP) has been demonstrated in numerous animal models of …