Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
EI Rogaev, R Sherrington, EA Rogaeva, G Levesque… - Nature, 1995 - nature.com
WE report the cloning of a novel gene (E5-1) encoded on chromosome 1 which has
substantial nucleotide and amino-acid sequence similarity to the S182 gene on …
substantial nucleotide and amino-acid sequence similarity to the S182 gene on …
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
R Sherrington, EI Rogaev, Y Liang, EA Rogaeva… - Nature, 1995 - nature.com
Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder
PH St George-Hyslop, JL Haines, LA Farrer, R Polinsky… - Nature, 1990 - nature.com
ALZHEIMER'S disease, a fatal neurodegenerative disorder of unknown aetiology, is usually
considered to be a single disorder because of tbe general uniformity of the disease …
considered to be a single disorder because of tbe general uniformity of the disease …
Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24. 3
C Van Broeckhoven, H Backhovens, M Cruts… - Nature …, 1992 - nature.com
Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the β–
amyloid protein precursor gene located in 21q21. 3 have indicated that early–onset …
amyloid protein precursor gene located in 21q21. 3 have indicated that early–onset …
Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families
CV Broeckhoven, AM Genthe, A Vandenberghe… - Nature, 1987 - nature.com
The gene coding for the amyloid protein, a component of neuritic plaques found in brain
tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and …
tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and …
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
A Goate, MC Chartier-Harlin, M Mullan, J Brown… - Nature, 1991 - nature.com
A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
P St George-Hyslop, J Haines, EI Rogaev, M Mortilla… - Nature …, 1992 - nature.com
Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a
very small proportion of early onset pedigrees being associated with mutations in the …
very small proportion of early onset pedigrees being associated with mutations in the …
[引用][C] Familial Alzheimer's chromosome 14 mutations
W Wasco, WP Pettingell, PD Jondro, SD Schmidt… - Nature medicine, 1995 - nature.com
(We have also identified two polymorphisms in the intronic sequences flanking this exon: An
A to C variant at nucleotide position-16 of the intron situated 3'of the exon; and an A to G …
A to C variant at nucleotide position-16 of the intron situated 3'of the exon; and an A to G …
The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene
RE Tanzi, PHS George-Hyslop, JL Haines, RJ Polinsky… - Nature, 1987 - nature.com
Amyloid β-protein (AP) is a peptide of relative molecular mass (M r) 42,000 found in the
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …
Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene
MC Chartier-Harlin, F Crawford, H Houlden, A Warren… - Nature, 1991 - nature.com
A MUTATION at codon 717 of the β-amyloid precursor protein gene has been found to
cosegregate with familial Alzheimer's disease in a single family1. This mutation has been …
cosegregate with familial Alzheimer's disease in a single family1. This mutation has been …
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