Evidence has accumulated that characterizes highly tumorigenic cancer cells residing in
heterogeneous populations. The accepted term for such a subpopulation is cancer stem …

The cancer stem cell (CSC) hypothesis is increasingly being accepted as a model to explain
for the functional heterogeneity that is commonly observed in solid tumors. According to this …

Despite major refinements in cancer therapy drugs, our progress at increasing the cure rates
of most cancers has been hampered by high relapse rates. A possible biological …

Background The Cancer Stem Cell (CSC) hypothesis has gained credibility within the
cancer research community. According to this hypothesis, a small subpopulation of cells …

Importance of the field: Cancer is the second leading cause of death in the United States,
and therefore remains a central focus of modern medical research. Accumulating evidence …

The recently developed concept of cancer stem cells (CSC) sheds new light on various
aspects of tumor growth and progression. Here, we present a mathematical model of …

Clinical oncology is in need of therapeutic innovation. New hypotheses and concepts for
translation of basic research to novel diagnostics and therapeutics are called for. In this …

Since the declaration of war on cancer some four decades ago, there has been an
exponential growth in our understanding of the genetic and cellular mechanisms that …

Overcoming resistance to standard anticancer treatments represents a significant challenge.
The interest regarding cancer stem cells, a cellular population that has the ability to self …

• Introduction• Molecular profiling for cancer classification• Molecular profiling of cancer stem
cells‐Historical perspective: cancer stem cells in leukaemia‐Molecular profiling of brain …