Background Non-invasive high-resolution imaging of the cerebral vascular anatomy and
function is key for the study of intracranial aneurysms, stenosis, arteriovenous …

Objective: Ultrasound Localization Microscopy (ULM) provides images of the
microcirculation in-depth in living tissue. However, its implementation in two-dimension is …

Technologies to visualize whole organs across scales in vivo are essential for our
understanding of biology in health and disease. To date, only post-mortem techniques …

Rationale: Structure and function of the microvasculature provides critical information about
disease state, can be used to identify local regions of pathology, and has been shown to be …

Abstract Changes in cerebral blood flow are associated with stroke, aneurysms, vascular
cognitive impairment, neurodegenerative diseases and other pathologies. Brain …

An increased pulse pressure, due to arteries stiffening with age and cardiovascular disease,
may lead to downstream brain damage in microvessels and cognitive decline. Brain-wide …

Non-invasive imaging deep into organs at microscopic scales remains an open quest in
biomedical imaging. Although optical microscopy is still limited to surface imaging owing to …

Aging-related cognitive decline is an emerging health crisis; however, no established
unifying mechanism has been identified for the cognitive impairments seen in an aging …

The advent of neuroimaging has increased our understanding of brain function. While most
brain-wide functional imaging modalities exploit neurovascular coupling to map brain …

Ultrasound Localization Microscopy (ULM) can resolve the microvascular bed down to a few
micrometers. To achieve such performance, microbubble contrast agents must perfuse the …