Different effects of eicosapentaenoic and docosahexaenoic acids on atherogenic high-fat diet-induced non-alcoholic fatty liver disease in mice

N Suzuki-Kemuriyama, T Matsuzaka, M Kuba, H Ohno… - PloS one, 2016 - journals.plos.org
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome,
can progress to steatohepatitis (NASH) and advanced liver damage, such as that from liver …

[HTML][HTML] Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr−/− mouse model of western …

CM Depner, KA Philbrick, DB Jump - The Journal of nutrition, 2013 - Elsevier
The incidence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis
(NASH) has increased in parallel with the incidence of obesity. While both NAFLD and …

Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice

T Shang, L Liu, J Zhou, M Zhang, Q Hu, M Fang… - Lipids in Health and …, 2017 - Springer
Background A sedentary lifestyle and poor diet are risk factors for the progression of non-
alcoholic fatty liver disease. However, the pathogenesis of hepatic lipid accumulation is not …

Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice

KA Lytle, CP Wong, DB Jump - PloS one, 2017 - journals.plos.org
Background Nonalcoholic fatty liver disease (NAFLD) is a major public health concern in
western societies. Nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD, is …

Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease

DB Jump, KA Lytle, CM Depner, S Tripathy - Pharmacology & therapeutics, 2018 - Elsevier
Obese and type 2 diabetic (T2DM) patients have a high prevalence of nonalcoholic fatty liver
disease (NAFLD). NAFLD is a continuum of chronic liver diseases ranging from benign …

Dietary Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) Operate by Different Mechanisms to Modulate Hepatic Steatosis and Hyperinsulemia in fa/fa …

L Hong, P Zahradka, L Cordero-Monroy, B Wright… - Nutrients, 2019 - mdpi.com
Hepatic steatosis, an early stage of non-alcoholic fatty liver disease, is commonly present in
obesity and type 2 diabetes, and is associated with reduced hepatic omega-3 …

n‐3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis

A Provenzano, S Milani, F Vizzutti, W Delogu… - Liver …, 2014 - Wiley Online Library
Background & Aims n‐3 polyunsaturated fatty acids (PUFA) ameliorate fatty liver in
experimental models, but their effects on inflammation and fibrosis during steatohepatitis are …

Potential treatment of human nonalcoholic fatty liver disease with long-chain omega-3 polyunsaturated fatty acids

DG Bouzianas, SD Bouziana, AI Hatzitolios - Nutrition reviews, 2013 - academic.oup.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in the
Western world. Its prevalence has increased with the growing obesity epidemic, yet no …

N-3 long-chain polyunsaturated fatty acid supplementation significantly reduces liver oxidative stress in high fat induced steatosis

R Valenzuela, A Espinosa, D González-Mañán… - 2012 - journals.plos.org
Omega-3 (n-3) long-chain polyunsaturated fatty acids (n-3 LCPUFA) are associated with
several physiological functions, suggesting that their administration may prevent non …

Dietary flaxseed oil prevents western‐type diet‐induced nonalcoholic fatty liver disease in apolipoprotein‐E knockout mice

H Han, F Qiu, H Zhao, H Tang, X Li… - Oxidative medicine and …, 2017 - Wiley Online Library
The prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically increased
globally during recent decades. Intake of n‐3 polyunsaturated fatty acids (PUFAs), mainly …