Objective—The ability of high-density lipoprotein (HDL) particles to accept cholesterol from
peripheral cells, such as lipid-laden macrophages, and to transport cholesterol to the liver …

Objective—We previously reported that a systemic liver X receptor (LXR) agonist promoted
macrophage reverse-cholesterol transport (mRCT) in vivo. Because LXR are expressed in …

The liver X receptors (LXRs) have been shown to affect lipoprotein plasma profile, lipid
metabolism, and reverse cholesterol transport (RCT). In the present study, we investigated …

Liver X receptor (LXR) activation promotes reverse cholesterol transport (RCT) in rodents
but has major side effects (increased triglycerides and LDL-cholesterol levels) in species …

Background—Liver X receptors (LXRs) are ligand-activated transcription factors involved in
the control of lipid metabolism and inflammation. Synthetic LXR agonists have been shown …

Liver X receptors (LXRs) are nuclear receptors that regulate macrophage cholesterol efflux
by inducing ATP-binding cassette transporter A1 (ABCA1) and ABCG1/ABCG4 gene …

Background The nuclear receptor liver X receptor (LXR) has two isoforms: LXRα and LXRβ.
LXR activation promotes cholesterol efflux in macrophages, but the relative importance of …

Recent studies have identified the liver X receptors (LXRα and LXRβ) as important
regulators of cholesterol metabolism and transport. LXRs control transcription of genes …

Objective—Liver X receptors (LXRs) are oxysterol-activated nuclear receptors regulating
reverse cholesterol transport, in part by modulating cholesterol efflux from macrophages to …

The nuclear oxysterol receptors LXRα (NR1H3) and LXRβ (NR1H2) coordinately regulate
the expression of genes involved in the transport and catabolism of cholesterol. In …