The expression of Platelet-derived Growth factor receptors (PDGFRs) and their correlation with overall survival of patients with ovarian cancer

S Szubert, R Moszynski, D Szpurek… - Ginekologia …, 2019 - journals.viamedica.pl
Objectives: The main aim of the study was to investigate the expression of Platelet-Derived
Growth Factor Receptors alpha (PDGFR-alpha) and beta (PDGFR-beta) in malignant and …

Immunohistochemical expression of platelet‐derived growth factor receptors in ovarian cancer patients with long‐term follow‐up

CV Madsen, K Dahl Steffensen… - Pathology Research …, 2012 - Wiley Online Library
Introduction. The well‐documented role of the PDGF system in tumor growth and
angiogenesis has prompted the development of new biological agents targeting the PDGF …

Platelet-derived growth factor receptor beta serum concentrations during first-line therapy in ovarian cancer

S Mathey, MK Graeser, C Zu Eulenburg, L Woelber… - Oncology, 2013 - karger.com
Objectives: Angiogenesis plays an important role in ovarian cancer. The interaction of
platelet-derived growth factor receptor-beta (PDGFR-β) with vascular endothelial growth …

Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms

R Henriksen, K Funa, E Wilander, T Bäckström… - Cancer research, 1993 - AACR
The expression of platelet-derived growth factor (PDGF), PDGF-α receptor (PDGFRα) and
PDGF-β receptor (PDGFRβ) was studied in normal ovaries and ovarian neoplasms by …

Autocrine activation of PDGFRα promotes the progression of ovarian cancer

D Matei, RE Emerson, YC Lai, LA Baldridge, J Rao… - Oncogene, 2006 - nature.com
Platelet-derived growth factor receptor (PDGFR) α expression was found in ovarian cancer
cells and tumors by microarray hybridization. This led us to test whether ovarian cancers …

The effects of platelet-derived growth factor and receptor on normal and neoplastic human ovarian surface epithelium

MB Dabrow, MR Francesco, FX McBrearty… - Gynecologic …, 1998 - Elsevier
Several growth factors have been shown to stimulate or inhibit the growth of human ovarian
surface epithelial (HOSE) cells. Platelet-derived growth factor (PDGF) is likely to be released …

Serum platelet-derived growth factor and fibroblast growth factor in patients with benign and malignant ovarian tumors

CV Madsen, KD Steffensen, DA Olsen… - Anticancer …, 2012 - ar.iiarjournals.org
Background: New biological markers with predictive or prognostic value are highly
warranted in the treatment of ovarian cancer. The platelet-derived growth factor (PDGF) …

PDGF BB induces VEGF secretion in ovarian cancer

D Matei, S Kelich, L Cao, N Menning… - Cancer biology & …, 2007 - Taylor & Francis
We identified the platelet derived growth factor receptor (PDGFR) as a potential target in
epithelial ovarian carcinoma (EOC). This led us to test whether inhibition of the PDGFR …

Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma

K Matsuo, M Nishimura, K Komurov, MMK Shahzad… - Gynecologic …, 2014 - Elsevier
Objective Platelet-derived growth factor receptor alpha (PDGFRα) is believed to be
associated with cell survival. We examined (i) whether PDGFRα blockade enhances the …

Expression of platelet-derived growth factor and activated receptor in clinical specimens of epithelial ovarian cancer and ovarian carcinoma cell lines

SM Apte, CD Bucana, JJ Killion, DM Gershenson… - Gynecologic …, 2004 - Elsevier
Objectives. We determined the expression of platelet-derived growth factor (PDGF), PDGF-
receptor (PDGF-R), and phosphorylated PDGF-R (p-PDGF-R) on tumor cells and tumor …