The primary objectives of this analysis were to determine which pharmacokinetic model
most accurately describes the elimination pathways for piperacillin in the presence of …

While extended infusions of piperacillin-tazobactam (TZP) are increasingly used in practice,
the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely …

Background: Prolonging the infusion of a β-lactam antibiotic enhances the time in which
unbound drug concentrations remain above the minimum inhibitory concentration (fT> MIC) …

The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …

Piperacillin-tazobactam is frequently used for empirical and targeted therapy of infections in
critically ill patients. Considerable pharmacokinetic (PK) variability is observed in critically ill …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

Standard doses of piperacillin/tazobactam (9–13.5 g over 24 h) administered by continuous
infusion (CI) routinely provide serum concentrations in excess of the susceptibility …

Piperacillin in combination with tazobactam is one of the most commonly used intravenous
antibiotics. There is evidence for a possible saturable elimination of piperacillin. Therefore …

In the present study 24 hospitalized patients requiring empirical antibiotic treatment were
randomly assigned to receive the β-lactam antibiotic/β-lactamase inhibitor combination …