Objectives To evaluate the pharmacokinetics of piperacillin/tazobactam in critically ill
patients undergoing continuous renal replacement therapy (CRRT) and to assess the …

Piperacillin/tazobactam is a new combination of a broad-spectrum penicillin and a beta-
lactamase inhibitor. In studies in healthy volunteers, the pharmacokinetics of piperacillin …

Methods: Blood samples (2–4 per child) were collected from 13 children ages 9 months to 6
years admitted to the pediatric intensive care unit who were receiving standard piperacillin …

Recent studies have shown that the pharmacodynamic (PD) index driving the efficacy of β-
lactam/β-lactamase inhibitor combinations such as ceftazidime/avibactam and ceftolozane …

Objective: To perform a qualitative systematic review of the evidence comparing traditional
strategies against prolonged intermittent or continuous infusion strategies for piperacillin …

Twenty-three generic intravenous piperacillin/tazobactam products were compared for in
vitro activity to the branded formulation (Zosyn®, Wyeth, Philadelphia, PA) by disk diffusion …

Study Objective. To compare conventional intermittent dosing regimens of piperacillin‐
tazobactam with prolonged and continuous infusions to determine the optimal dosing …

Piperacillin plasma concentrations are known to vary between critically ill patients. However,
there are no comprehensive data on the variability of antibiotic concentrations within the …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Despite the clinical use of piperacillin
for more than two decades, there are still contradictory reports whether or not the elimination …