Clinical efficacy and pharmacoeconomics of a continuous‐infusion piperacillin‐tazobactam program in a large community teaching hospital
EM Grant, JL Kuti, DP Nicolau… - … : The Journal of …, 2002 - Wiley Online Library
Study Objective. To compare continuous versus intermittent administration of piperacillin‐
tazobactam with regard to clinical, microbiologic, and economic outcomes. Design …
tazobactam with regard to clinical, microbiologic, and economic outcomes. Design …
Population pharmacokinetic modeling and Monte Carlo simulation of varying doses of intravenous metronidazole
KA Sprandel, GL Drusano, DW Hecht… - … and infectious disease, 2006 - Elsevier
Population pharmacokinetic modeling and Monte Carlo simulation (MCS) are approaches
used to determine probability of target attainment (PTA) of antimicrobial therapy. The …
used to determine probability of target attainment (PTA) of antimicrobial therapy. The …
The retrospective cohort of extended‐infusion piperacillin‐tazobactam (RECEIPT) study: a multicenter study
RJ Yost, DM Cappelletty… - … : The Journal of …, 2011 - Wiley Online Library
Study Objective. To compare the effectiveness of extended‐infusion piperacillin‐tazobactam
with that of similar‐spectrum, nonextended‐infusion β‐lactam antibiotics in the treatment of …
with that of similar‐spectrum, nonextended‐infusion β‐lactam antibiotics in the treatment of …
Rationale and evidence for extended infusion of piperacillin–tazobactam
SE Kaufman, RW Donnell… - American Journal of …, 2011 - academic.oup.com
Purpose The pharmacodynamics and therapeutic effects of extended-infusion (EI)
piperacillin–tazobactam therapy are reviewed, with an emphasis on growing evidence of its …
piperacillin–tazobactam therapy are reviewed, with an emphasis on growing evidence of its …
Using population pharmacokinetic modeling and Monte Carlo simulations to determine whether standard doses of piperacillin in piperacillin-tazobactam regimens are …
Changes in the pharmacokinetics of piperacillin in febrile neutropenic patients have been
reported to result in suboptimal exposures. This study aimed to develop a population …
reported to result in suboptimal exposures. This study aimed to develop a population …
Importance of beta-lactamase inhibitor pharmacokinetics in the pharmacodynamics of inhibitor-drug combinations: studies with piperacillin-tazobactam and …
PD Lister, AM Prevan, CC Sanders - Antimicrobial agents and …, 1997 - Am Soc Microbiol
An in vitro pharmacokinetic model was used to study the pharmacodynamics of piperacillin-
tazobactam and piperacillin-sulbactam against gram-negative bacilli producing plasmid …
tazobactam and piperacillin-sulbactam against gram-negative bacilli producing plasmid …
In vitro pharmacodynamics of piperacillin, piperacillin-tazobactam, and ciprofloxacin alone and in combination against Staphylococcus aureus, Klebsiella pneumoniae …
JM Hyatt, DE Nix, CW Stratton… - Antimicrobial agents and …, 1995 - Am Soc Microbiol
The time-kill curve methodology was used to determine the pharmacodynamics of
piperacillin, ciprofloxacin, piperacillin-tazobactam and the combinations piperacillin …
piperacillin, ciprofloxacin, piperacillin-tazobactam and the combinations piperacillin …
Expanded studies of piperacillin/tazobactam formulations: variations among branded product lots and assessment of 46 generic lots
The experience with analyzing the potency of piperacillin/tazobactam generic formulations
by a precise multiorganism in vitro assay was expanded to 46 lots (29 manufacturers, 17 …
by a precise multiorganism in vitro assay was expanded to 46 lots (29 manufacturers, 17 …
Steady-state pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese patients
SC Cheatham, MR Fleming, DP Healy… - International journal of …, 2013 - Elsevier
The study objective was to evaluate steady-state pharmacokinetics and pharmacodynamics
of piperacillin and tazobactam administered by prolonged infusion in obese patients …
of piperacillin and tazobactam administered by prolonged infusion in obese patients …
Pharmacokinetics of an extended 4‐hour infusion of piperacillin‐tazobactam in critically ill patients undergoing continuous renal replacement therapy
DK Awissi, A Beauchamp, E Hébert… - … : The Journal of …, 2015 - Wiley Online Library
Study Objective To evaluate the pharmacokinetic and pharmacodynamic profiles of
piperacillin‐tazobactam administered as a 4‐hour infusion in critically ill patients undergoing …
piperacillin‐tazobactam administered as a 4‐hour infusion in critically ill patients undergoing …