Study Objective. To compare continuous versus intermittent administration of piperacillin‐
tazobactam with regard to clinical, microbiologic, and economic outcomes. Design …

Population pharmacokinetic modeling and Monte Carlo simulation (MCS) are approaches
used to determine probability of target attainment (PTA) of antimicrobial therapy. The …

Study Objective. To compare the effectiveness of extended‐infusion piperacillin‐tazobactam
with that of similar‐spectrum, nonextended‐infusion β‐lactam antibiotics in the treatment of …

Purpose The pharmacodynamics and therapeutic effects of extended-infusion (EI)
piperacillin–tazobactam therapy are reviewed, with an emphasis on growing evidence of its …

Changes in the pharmacokinetics of piperacillin in febrile neutropenic patients have been
reported to result in suboptimal exposures. This study aimed to develop a population …

An in vitro pharmacokinetic model was used to study the pharmacodynamics of piperacillin-
tazobactam and piperacillin-sulbactam against gram-negative bacilli producing plasmid …

The time-kill curve methodology was used to determine the pharmacodynamics of
piperacillin, ciprofloxacin, piperacillin-tazobactam and the combinations piperacillin …

The experience with analyzing the potency of piperacillin/tazobactam generic formulations
by a precise multiorganism in vitro assay was expanded to 46 lots (29 manufacturers, 17 …

The study objective was to evaluate steady-state pharmacokinetics and pharmacodynamics
of piperacillin and tazobactam administered by prolonged infusion in obese patients …

Study Objective To evaluate the pharmacokinetic and pharmacodynamic profiles of
piperacillin‐tazobactam administered as a 4‐hour infusion in critically ill patients undergoing …