The ability of environmental factors to promote a phenotype or disease state not only in the
individual exposed but also in subsequent progeny for successive generations is termed …

Variations in phenotype reflect the influence of environmental conditions during
development on cellular functions, including that of the genome. The recent integration of …

The molecular processes underlying human health and disease are highly complex. Often,
genetic and environmental factors contribute to a given disease or phenotype in a non …

Developmental origins of health and disease (DOHaD) is the study of how the early life
environment can impact the risk of chronic diseases from childhood to adulthood and the …

Rapidly growing evidences link maternal lifestyle and prenatal factors with serious health
consequences and diseases later in life. Extensive epidemiological studies have identified a …

Decades of animal, clinical, and population-based research suggest that events that occur at
the earliest stages of human development may lead to longterm, sometimes irreversible …

Exposures to adverse environments, both psychosocial and physicochemical, are prevalent
and consequential across a broad range of childhood populations. Such adversity …

The ongoing epidemic of chronic diseases involves a spectrum of clinical entities now
understood to represent late manifestations of progressive metabolic dysfunction initiated in …

A now substantial body of science implicates a dynamic interplay between genetic and
environmental variation in the development of individual differences in behavior and health …

Severe or chronic stress and trauma can have a detrimental impact on health. Evidence
suggests that early-life adversity can become biologically embedded and has the potential …